Results 251 to 260 of about 39,430 (282)
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Isolation of human complement factors C3, C5 and H
Journal of Immunological Methods, 1985An improved method for simultaneous purification of complement factors C3, C5 and H from human plasma has been developed. Using an initial batch separation technique with QAE-Sephadex, followed by chromatography on SP-Sephadex and gel filtration in Sephadex G-200, 600 mg of highly pure C3 can be prepared from 1600 ml of plasma.
A, Lundwall, G, Eggertsen
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Magnetic bead based assays for complement component C5
Journal of Immunological Methods, 2017Two novel magnetic agarose bead based assays have been developed to measure complement component C5 interaction with C3b and the Factor I Modules (FIMs) of C7. One innovation was to couple C3b onto the magnetic agarose bead using the alternative pathway C3 convertase, which resulted in a linkage of the ligand by a covalent ester bond.
Richard G. DiScipio +1 more
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Derivation of RNA aptamer inhibitors of human complement C5
Immunopharmacology, 1999Specific aptamer inhibitors of the human complement C5 component were produced by the SELEX methodology of directed evolution of nucleic acid ligands. The SELEX procedure started with a pool of random-sequence, 2'F-pyrimidine-modified nuclease-stabilized RNA, and after twelve rounds of iterative C5 binding and nucleic acid amplification an evolved RNA ...
G, Biesecker +3 more
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Structure, Function and Control of Complement C5 and its Proteolytic Fragments
Current Molecular Medicine, 2012As part of the innate immune system, the complement system recognises a wide range of non-self structures present on pathogens or altered self cells. Its activation elicits proteolytic cascades which eventually results in the cleavage of the C5 protein into two fragments, C5a and C5b.
Laursen, Nick Stub +4 more
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[Inhibition of formation of complement C5-convertase].
Bioorganicheskaia khimiia, 1998Control of the formation of complement C5-convertase is an important factor in maintaining human homeostasis. Some physiologically active endogenous and exogenous substances were shown to be capable of exerting such control. A method was developed for studying the influence of the effectors on the formation of classical-complement-pathway C5-convertase
L V, Kozlov, T V, Lebedeva
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Overexpression of complement C5 in endometriosis
Clinical Biochemistry, 2014Aslan, Cigdem +7 more
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Staphylococcus disrupts complement activation
Nature Reviews Microbiology, 2021Grant Otto, Otto Grant
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A guide to complement biology, pathology and therapeutic opportunity
Nature Reviews Immunology, 2023Dimitrios C Mastellos +2 more
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