Results 121 to 130 of about 1,060,485 (284)

The Relationship between the complement system and subclinical carotid atherosclerosis in patients with rheumatoid arthritis

Arthritis Research & Therapy
Background Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) events and CV mortality. Subclinical carotid atherosclerosis is independently associated with rates of incident CV events among patients with RA.
Marta Hernández-Díaz, Dara Rodríguez-González, Elena Heras-Recuero, Fuensanta Gómez-Bernal, Juan Carlos Quevedo-Abeledo, Agustín F. González-Rivero, Elena González-López, J. Gonzalo Ocejo-Vinyals, Alejandro Jimenez-Sosa, Miguel Ángel González-Gay, Iván Ferraz-Amaro   +10 more
doaj   +1 more source

Therapeutic advances in eculizumab for atypical hemolytic uremic syndrome: a narrative review

Frontiers in Pharmacology
Atypical hemolytic uremic syndrome (aHUS) represents an uncommon, life-threatening complement-mediated thrombotic microangiopathy that is linked to both significant renal and extrarenal complications.
Dandan Zhang, Yichen Xiao, Hualin Ma, Hualin Ma, Hualin Ma   +4 more
doaj   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

The Challenges of Green Human Resource Management and Their Impact on Employees' Green Beliefs, Attitudes and Behaviours: The Case of the Nigerian Oil and Gas Industry

Business Strategy and the Environment, EarlyView.
ABSTRACT Green human resource management is increasingly recognised as essential for integrating environmental concerns into organisational strategies. Drawing on qualitative data from 30 professionals in Nigeria's oil and gas industry, this study explores how inconsistencies between employees' environmental values and GHRM practices influence ...
Winifred Aina, Sachiko Takeda, Yumei Yang   +2 more
wiley   +1 more source

Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle

Chemistry – A European Journal, EarlyView.
Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou, Jinbiao Jiao, Mathieu Lordez, Jean‐Yves Salpin, Juan Xie   +4 more
wiley   +1 more source

Viral infections and related fatal adverse events associated with complement inhibitors for PNH: a real-world pharmacovigilance analysis in FAERS

Frontiers in Pharmacology
BackgroundComplement inhibitors are increasingly utilized across various clinical indications, including the treatment of paroxysmal nocturnal hemoglobinuria (PNH).
Jinman Zhong, Chang Chen, Yunman Xu, Yueping He, Jiewen Tan, Dan Xiong   +5 more
doaj   +1 more source

Design and Biological Evaluation of the Long-Acting C5-Inhibited Ornithodoros moubata Complement Inhibitor (OmCI) Modified with Fatty Acid

Disorder of complement response is a significant pathogenic factor causing some autoimmune and inflammation diseases. The Ornithodoros moubata Complement Inhibitor (OmCI), a small 17 kDa natural protein, was initially extracted from soft tick salivary ...
Xiaowan Li (3336774), Yandan Wang (741329), Yuanzhen Dong (11284302), Jun Feng (116162), Zongqing Huang (18333860), Wenwen Shangguan (10223915), Meiqing Feng (447657)   +6 more
core   +1 more source

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

, 2009
Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have
Fredslund, F, Bjerre, M, Gordon, NL, Hermans, Stefan, Anderssen, G, Wines, B, Jackson, NJH, Christensen, JB, Laursen, NS, Spillner, E, Lorenz, Natalie, Sottrup-Jensen, L, Jensen, M, Fraser, John   +13 more
core   +1 more source

Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion

Chemistry – A European Journal, EarlyView.
An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang, Nemanja Djokovic, Alexander Herr, Anna Wacker, Emily Swanson Hay, Daniel Santana, Amanda E. Hargrove, Harald Schwalbe, Katarina Nikolic, Frank Abendroth, Olalla Vázquez   +10 more
wiley   +1 more source

Crovalimab: A Novel Approach in the Management of Paroxysmal Nocturnal Hemoglobinuria

Health Science Reports
Background and Aims Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare acquired clonal blood disorder caused by mutations in the PIGA gene, leading to complement‐mediated hemolysis.
Laiba Jalal, Marium Ahmed, Anum Khalid
doaj   +1 more source