Results 131 to 140 of about 1,060,485 (284)

Detection of antibody-dependent complement mediated inactivation of both autologous and heterologous virus in primary HIV-1 infection [PDF]

, 2005
Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication.
Aubin, K., Williams, I., Jones, N.A., Borrow, P., Holuigue, S., Cornforth, D., Wong, M., Pellegrino, P., McKnight, A., Aasa-Chapman, M.M.I., Newton, P.   +10 more
core  

GH172 Difructose Dianhydride I Synthase: A Two‐Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics

Chemistry – A European Journal, EarlyView.
Unlocking the chemistry of caramel by simulations and experimental validation. αFFase1${\alpha }\rm{FFase1}$ converts inulobiose into difructose dianhydride I, one component of caramel, through two steps: a rate‐limiting glycosylation (with a rare sugar ring flip) followed by a cyclization step, guided by residues E85, K147, and N226.
Santiago Alonso‐Gil, Bruno Di Geronimo, Toma Kashima, Akihiro Ishiwata, Katsunori Tanaka, Kiyotaka Fujita, Shinya Fushinobu, Pedro A. Sánchez‐Murcia   +7 more
wiley   +1 more source

Meningococcemia in a Boy with Dense Deposit Disease Receiving the C5 Complement Inhibitor Ravulizumab: A Case Report

Clinical Practice and Cases in Emergency Medicine
Introduction: Dense deposit disease, also known as C3 glomerulopathy, is a rare renal disorder caused by abnormal complement deposition in the glomerular basement membrane. Patients often require long-term immunosuppressive therapy and, in some cases, complement inhibitors such as ravulizumab.
Andrew Gonedes, Alexandra Martinez, Allan M. Greissman, Hanan Atia, Eric Boccio   +4 more
openaire   +1 more source

Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata

, 2005
Blood-feeding ticks must control C activation or be damaged by the host inflammatory response. We report the characterization and expression of a novel, relatively small, broad-acting C inhibitory protein (termed OmCI) from the soft tick Ornithodoros ...
Lissina, Olga, Nuttall, Patricia A., Sharma, Ankit, Willis, Anthony C., Paesen, Guido C., Nunn, Miles A., Adamson, Sharon   +6 more
core   +3 more sources

Halogenated Tryptophans Improve Integrin αVβ6 Affinity of Cyclic RGD Peptides and Provide Handles for Late‐Stage Derivatization

Chemistry – A European Journal, EarlyView.
Lighting up αVβ6: Halotryptophan engineering converts an RGD scaffold into a modular αVβ6 ligand platform, enabling picomolar affinity and late‐stage functionalization. The resulting probes combine high selectivity with fluorescence for FACS and tumor imaging.
Beate Nachtigall, Caroline Brinkmann, Jana Langosch, Anke Nieß, Norbert Sewald   +4 more
wiley   +1 more source

Human in vitro neuromuscular junction model to functionally dissect the pathogenic mechanism of anti-AChR autoantibody-positive myasthenia gravis

BMC Pharmacology and Toxicology
Background Myasthenia gravis is a rare autoimmune disease mediated by autoantibodies directed against acetylcholine receptors (AChRs) at the neuromuscular junction.
Baehyun Shin, Monica Wang, John Yim, Elisa Kwon, Margaret H. Magdesian, Camil E. Sayegh, Jason E. Ekert, Douangsone D. Vadysirisack   +7 more
doaj   +1 more source

Comprehensive Evaluation of Commercial Antibodies for High Sensitivity Detection of EPO‐Doping on Western Blots

Drug Testing and Analysis, EarlyView.
A large‐scale evaluation of 164 commercially available anti‐human EPO antibodies was conducted to identify an alternative to clone AE7A5 anti‐EPO antibody used in doping control for the detection of erythropoiesis‐stimulating agents (ERAs) on Western blots.
Christian Reichel, Günter Gmeiner, Hans Geyer, Mario Thevis   +3 more
wiley   +1 more source

Low‐Temperature in Situ Upgrading of Ultra‐Deep Heavy Oil Using Ni–Ce/MOF–OTf Superacid Catalysts to Enhance Energy Utilization and Sustainability

EcoEnergy, EarlyView.
A triflate‐functionalized Ni–Ce/MOF–OTf superacid enables low‐temperature (∼140°C) in situ upgrading of ultra‐deep heavy oil. It reduces viscosity by 92.11% in 12 h, maintains activity over cycles, and delivers 90.25% recovery with a lower carbon footprint by selective bond cleavage. ABSTRACT Ultra‐deep heavy oil is an important unconventional resource,
Li Wang, Ji‐Xiang Guo, Qiming Huang, Kunpeng Li, Chi Li, Yajie Wu   +5 more
wiley   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

FcRn Inhibitor Combination with C5 Complement Blockade for Refractory MG

Dual targeting of FcRn (FCGRT, Open Targets score 0.59) and complement C5 (score 0.57) addresses both pathogenic antibody recycling and complement-mediated neuromuscular junction damage. ChEMBL compounds CHEMBL508564 and CHEMBL508411 target FCGRT, while existing drugs like eculizumab target C5.
openaire   +1 more source