Results 171 to 180 of about 1,060,485 (284)

Beyond Terminal Blockade: A Mechanism-Based Approach to Complement Inhibitor Selection in Paroxysmal Nocturnal Hemoglobinuria. [PDF]

Drug Des Devel Ther
Chen C, Zhong J, Xiong D.
europepmc   +1 more source

Clonal Dynamics of GPI‐Deficient Cells in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH): A Retrospective Follow‐Up Analysis

European Journal of Haematology, EarlyView.
ABSTRACT This retrospective, single‐center study aimed to characterize clonal dynamics of GPI‐deficient cells in patients with paroxysmal nocturnal hemoglobinuria (PNH) or PNH/aplastic anemia (AA) syndrome using multiparameter flow cytometry including FLAER.
Sandra M. Frey, Friederike Poppenborg, Ute Schmücker, Nicole Preising, H. Christian Reinhardt, Alexander Röth, Ferras Alashkar   +6 more
wiley   +1 more source

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

Switching between complement inhibitors in paroxysmal nocturnal hemoglobinuria: Analysis of strategy, efficacy, and safety. [PDF]

Hemasphere
Griffin M, Fattizzo B, Lee JW, Kelly RJ, Trikha R, Ueda Y, Nishimura JI, Patriquin CJ, Röth A, Muus P, Panse J, Álvarez MG, Pike A, Munir T, Gandhi S, Kulasekararaj A.   +15 more
europepmc   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection? [PDF]

Eur J Immunol
Bettoni S, Qviberg E, Chaloner E, Lavender H, Laabei M.   +4 more
europepmc   +1 more source

Recombinant Ornithodoros moubata Saliva-derived Small Protein Complement C5 Inhibitor [PDF]

, 2020
openaire   +1 more source

Impaired Phagocytosis in Peritonitis Exudate Secondary to Complement Consumption [PDF]

, 1988
Billing, A., Jochum, Marianne, Fröhlich, D., Kortmann, H.   +3 more
core   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Systems Pharmacology Approach to Paroxysmal Nocturnal Hemoglobinuria: Quantitative Framework for Biomarker Dynamics across Multi-Mechanistic Therapies. [PDF]

Clin Pharmacol Ther
Cruikshank A, Yang Y, Liu G, Liu J, Zhu H.   +4 more
europepmc   +1 more source