Results 181 to 190 of about 1,060,485 (284)

Crystal structure and biochemical analysis of the polyester‐degrading carboxylesterase SM0281 from the symbiotic legume‐associated rhizobacterium Sinorhizobium (Ensifer) meliloti

The FEBS Journal, EarlyView.
The microbial degradation of synthetic polyesters such as polyethylene terephthalate (PET) is mediated by diverse α/β‐hydrolases, many of which remain poorly characterized. In this study, we investigated the α/β‐hydrolase SM0281 from Sinorhizobium meliloti and found that it exhibits robust carboxylesterase and polyesterase activities toward PET, PCL ...
Sofia Lemak, Anna N. Khusnutdinova, Peter J. Stogios, Elena Evdokimova, Alexei Savchenko, Peter N. Golyshin, Elizabeth A. Edwards, Alexander F. Yakunin   +7 more
wiley   +1 more source

The new era of treatments for kidney transplant recipients. [PDF]

J Bras Nefrol
Silva Junior HT.
europepmc   +1 more source

Australian consensus recommendations for the management of increased meningococcal infection risk in adults with neurological diseases treated with complement inhibitors

Internal Medicine Journal, EarlyView.
Abstract Complement inhibitor therapy carries a risk of serious infections, including meningococcal disease. Here we provide evidence‐based recommendations and expert consensus for immunisation and prophylactic treatment of patients receiving, or planning to receive, complement inhibitors for neurological conditions in the Australian setting.
Katherine A. Buzzard, Michael Barnett, Heidi Beadnall, Mirasol Forcadela, Lesley‐Ann Hall, Victoria G. Hall, Todd Hardy, Danny Hsu, Paul Kinsella, Mastura Monif, Sudarshini Ramanathan, Stephen W. Reddel, Sean Riminton, Douglas F. Johnson   +13 more
wiley   +1 more source

Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition

Immunology, EarlyView.
We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek   +5 more
wiley   +1 more source

Complement-targeted therapies for C3 glomerulopathy and atypical hemolytic uremic syndrome: a time-limited rapid systematic review with narrative synthesis. [PDF]

Front Med (Lausanne)
Wu Q, Yu Z, Wu Z, Yang L, Lin X.
europepmc   +1 more source

The Agencies of the European Union: A Glimmer of Hope for Enlargement?

JCMS: Journal of Common Market Studies, EarlyView.
Abstract In recent years, the process of EU enlargement has become increasingly difficult. The longer the process drags on and the less likely accession appears, the more the candidate states are discouraged and the less influential the EU becomes. A different approach to integration must therefore be used.
Matis Poussardin
wiley   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor. [PDF]

J Clin Lab Anal
Liu H, Che M, Li L, Wang H, Wang C, Wu J, Chen Y, Liu Z, Li L, Fu R.   +9 more
europepmc   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Treatment of antibody-mediated rejection in heart transplantation: from empirical combination to multi-target precision intervention. [PDF]

Front Immunol
Xu N, Dong Y, Yue Y, Zhou L.
europepmc   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source