Results 241 to 250 of about 38,195 (255)

The Role of Complement Activation in Diabetic Nephropathy: Current Insights and Future Directions. [PDF]

J Clin Med
Kotsalas N, Fouza A, Daoudaki M.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Complement component 5a (C5a)

The International Journal of Biochemistry & Cell Biology, 2009
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert
Manthey, Helga D., Woodruff, Trent M., Taylor, Stephen M., Monk, Peter N.   +3 more
openaire   +3 more sources

C5L2: a controversial receptor of complement anaphylatoxin, C5a

The FASEB Journal, 2012
C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a single, G‐protein‐coupled, C5a receptor (C5aR; also termed CD88). In 2000, a second C5a receptor, C5L2 (previously known as GPR77), was discovered; yet, despite 12 yr of intensive research, its biological ...
Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M., Woodruff, Trent M.   +4 more
openaire   +3 more sources

Complement C5a Receptor Assay for High Throughput Screening

Journal of Receptor Research, 1991
The complement C5a receptor on U937 cells, a human histiocytic lymphoma cell line, stimulated with dibutyryl-cAMP have been stabilized for at least 3 months at a dilute, ready to use concentration. [125I]-Bolton Hunter labeled C5a, (recombinant, human) has been prepared by reverse phase HPLC to 2200 Ci/mmol. Using a filtration binding assay the Kd from
S R, Harris, R K, Garlick, J J, Miller, H N, Harney, P J, Monroe   +4 more
openaire   +2 more sources

Circular dichroism of C5a anaphylatoxin of porcine complement

Biochemical and Biophysical Research Communications, 1974
Abstract The far-ultraviolet circular dichroism spectrum of C5a anaphylatoxin of porcine complement implies that it has a substantial content of helical structure. The circular dichroism spectra of C5a in the 200–250 nm region at pH 7.2 and 3.7 are nearly identical and resemble those of C3a anaphylatoxin.
W T, Morgan, E H, Vallota, H J, Müller-Eberhard   +2 more
openaire   +2 more sources

C5a, but not C5a‐des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2

Immunology & Cell Biology, 2013
Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Croker, Daniel E., Halai, Reena, Fairlie, David P., Cooper, Matthew A.   +3 more
openaire   +3 more sources

Mesenteric dysfunction after cardiopulmonary bypass: role of complement C5a

The Annals of Thoracic Surgery, 2000
We investigated the effects of cardiopulmonary bypass (CPB) on ileal homeostasis, and the influence of functional inhibition of complement C5a on CPB-induced mesenteric injury.Pigs were perfused on CPB for 1 hour and then perfused off CPB for an additional 2 hours.
M, Tofukuji, G L, Stahl, C, Metais, M, Tomita, A, Agah, C, Bianchi, M P, Fink, F W, Sellke   +7 more
openaire   +2 more sources

Complement C5a inhibition reduces atherosclerosis in ApoE ^–/– mice

The FASEB Journal, 2011
ABSTRACT The complement C5a receptor, CD88, is present on many of the cells found within human atherosclerotic plaques, but little is known about the role of C5a in atherogenesis. Using real‐time PCR, we determined that ApoE –/–
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara, Taylor, Stephen M.   +6 more
openaire   +3 more sources

Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity

Journal of Cellular Biochemistry, 1999
Previous work from this laboratory indicates a role for the complement component C5 in neuroprotection against excitotoxicity. In the present study, we tested the hypothesis that the C5-derived anaphylatoxin C5a protects against kainic acid (KA)-induced neurodegeneration and investigated the mechanism of C5a neuronal activity in vitro.
H, Osaka, P, Mukherjee, P S, Aisen, G M, Pasinetti   +3 more
openaire   +2 more sources

Involvement of complement peptides C3a and C5a in osteoarthritis pathology

Peptides, 2022
Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five diseases in Germany causing the highest suffering of the patients and cost for the society. The quality of life of OA patients is severely compromised, and adequate therapy is lacking owing to a knowledge gap that acts as a major barrier to finding safe and ...
Nicole, Schäfer, Susanne, Grässel
openaire   +2 more sources