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Complement C5a: Impact on the field of veterinary medicine

The Veterinary Journal, 2012
Complement C5a is a pro-inflammatory polypeptide produced during activation of the complement cascade in response to foreign antigens or tissue damage secondary to physical or chemical injury. C5a, via activation of the C5a receptor (C5aR or CD88), is a major inflammatory mediator involved in a number of diseases, including some of veterinary relevance.
Hezmee, M. N. M.   +3 more
openaire   +3 more sources

Cardiopulmonary Bypass-induced Complement Activation. Evidence for C5a Participation

The International Journal of Artificial Organs, 1982
Plasma activity inducing polymorphonuclear neutrophils (PMN) aggregation, augmenting PMN adherence, plasma chemotatic activity as well as peripheral PMN count were estimated in patients during cardiopulmonary bypass. In the course of the surgical procedure the chemotactic activity and the activity inducing PMN aggregation were detected in plasma.
H, Wysocki   +4 more
openaire   +2 more sources

PTX3 Deficiency Aggravates Periodontitis by the Complement C5a-C5aR1 Axis

Journal of Dental Research
Dysregulation of the complement system plays a critical role in periodontitis progression. In addition to the harmful effects of biofilm, aberrant expression of complement regulatory proteins is also a potential cause of periodontitis. Pentraxin 3 (PTX3) is involved in complement activation and regulation, seeking a balance between amplifying ...
W. Dong, D. Guo, C. Yang, Q. Xu, J. Wang
openaire   +2 more sources

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