Results 101 to 110 of about 1,348,900 (304)

Elucidating the Immune Evasion Mechanisms of Borrelia mayonii, the Causative Agent of Lyme Disease

Frontiers in Immunology, 2019
Borrelia (B.) mayonii sp. nov. has recently been reported as a novel human pathogenic spirochete causing Lyme disease (LD) in North America. Previous data reveal a higher spirochaetemia in the blood compared to patients infected by LD spirochetes ...
Lea Walter, Valerie Sürth, Florian Röttgerding, Peter F. Zipfel, Peter F. Zipfel, Karin Fritz-Wolf, Karin Fritz-Wolf, Peter Kraiczy   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Alteraciones del sistema complemento en pacientes con anemia drepanocítica en estado basal Alterations of the complement system in patients with basal sickle cell anemia

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2001
Se determinó la actividad de las vías clásica y alternativa del complemento, así como la cuantificación de algunos de sus componentes en 46 pacientes con anemia drepanocítica (AD) (hemoglobina SS), 21 sin complicaciones clínicas y 25 con estas; entre las
Rinaldo Villaescusa Blanco, Ada A Arce Hernández, Orlando Serrano Barrera, Julio C Merlín Linares, Ana M Guerreiro Hernández, Luz M Morera Barrios, Edgardo Espinosa Martínez   +6 more
doaj  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Potential benefits and risks of clinical xenotransplantation [PDF]

, 2012
The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core   +2 more sources

Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

Journal of Neuroinflammation, 2007
Background The posttraumatic response to traumatic brain injury (TBI) is characterized, in part, by activation of the innate immune response, including the complement system.
Holers V Michael, Ward Peter A, Rittirsch Daniel, Taha Mohy E, Hossini Amir M, Schmidt Oliver I, Thurman Joshua M, Harhausen Denise, Rozanski Michal, Leinhase Iris, Ertel Wolfgang, Stahel Philip F   +11 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Numerical assessment of the percolation threshold using complement networks [PDF]

, 2018
Models of percolation processes on networks currently assume locally tree-like structures at low densities, and are derived exactly only in the thermodynamic limit.
Caldarelli, Guido, Cimini, Giulio, Rapisardi, Giacomo   +2 more
core   +2 more sources

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study.

PLoS Neglected Tropical Diseases
BackgroundNumerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement
Anuradha Rajamanickam, Bindu Dasan, Saravanan Munisankar, Sujatha Nott, Pradeep A Menon, Fayaz Ahamed Shaik, Ponnuraja Chinnaiyan, Thomas B Nutman, Subash Babu   +8 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source