Results 111 to 120 of about 2,034,857 (344)

On a von Neumann algebra which is a complemented subspace [PDF]

arXiv, 2013
Let M be a von Neumann algebra of type II_1 which is also a complemented subspace of B(H). We establish an algebraic criterion, which ensures that M is an injective von Neumann algebra. As a corollary we show that if M is a complemented factor of type II_1 on a Hilbert space H, then M is injective if its fundamental group is non-trivial.
arxiv  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Elucidating the Immune Evasion Mechanisms of Borrelia mayonii, the Causative Agent of Lyme Disease

Frontiers in Immunology, 2019
Borrelia (B.) mayonii sp. nov. has recently been reported as a novel human pathogenic spirochete causing Lyme disease (LD) in North America. Previous data reveal a higher spirochaetemia in the blood compared to patients infected by LD spirochetes ...
Lea Walter, Valerie Sürth, Florian Röttgerding, Peter F. Zipfel, Peter F. Zipfel, Karin Fritz-Wolf, Karin Fritz-Wolf, Peter Kraiczy   +7 more
doaj   +1 more source

$B\to D^{(\ast)}\ellν$ at non-zero recoil [PDF]

PoS(LATTICE2022)250, 2022
$B$ anomalies play a prominent role in Beyond the Standard Model (BSM) physics searches. In particular, the long standing tension between the inclusive and the exclusive determinations of the CKM matrix element $|V_{cb}|$ and the current tensions in the $R(D)$--$R(D^\ast)$ plane between theory and experiment have brought the $B\to D^{(\ast)}\ell\nu ...
arxiv  

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study.

PLoS Neglected Tropical Diseases
BackgroundNumerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement
Anuradha Rajamanickam, Bindu Dasan, Saravanan Munisankar, Sujatha Nott, Pradeep A Menon, Fayaz Ahamed Shaik, Ponnuraja Chinnaiyan, Thomas B Nutman, Subash Babu   +8 more
doaj   +1 more source

Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

Journal of Neuroinflammation, 2007
Background The posttraumatic response to traumatic brain injury (TBI) is characterized, in part, by activation of the innate immune response, including the complement system.
Holers V Michael, Ward Peter A, Rittirsch Daniel, Taha Mohy E, Hossini Amir M, Schmidt Oliver I, Thurman Joshua M, Harhausen Denise, Rozanski Michal, Leinhase Iris, Ertel Wolfgang, Stahel Philip F   +11 more
doaj   +1 more source

Coexistence of Closed and Open Conformations of Complement Factor B in the Alternative Pathway C3bB(Mg2+) Proconvertase12

Journal of Immunology, 2009
Complement factor B (fB) circulates in plasma as a proenzyme that, upon binding to C3b in the presence of Mg2+, is cleaved by factor D to produce Ba and Bb fragments.
Eva Torreira, A. Tortajada, T. Montes, S. Rodríguez de Córdoba, O. Llorca   +4 more
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4

BMC Microbiology, 2010
Background B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Zipfel Peter F, Schuijt Tim J, Kraiczy Peter, van Burgel Nathalie D, van Dam Alje P   +4 more
doaj   +1 more source