Results 121 to 130 of about 367,967 (298)

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Mutational Analysis of the Primary Substrate Specificity Pocket of Complement Factor B [PDF]

, 2000
Yuanyuan Xu, Antonella Circolo, Jing Hua, Yue Wang, Sthanam V.L. Narayana, John E. Volanakis   +5 more
openalex   +1 more source

A new TaqI polymorphism of the complement factor B gene [PDF]

Nucleic Acids Research, 1988
Gérard Lefranc, N. Ghanem, J M Lobaccaro, C Sultan   +3 more
openaire   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Ancient origins: complement in invertebrates [PDF]

Invertebrate Survival Journal, 2005
Proteins with obvious similarities to mammalian complement are widely distributed in the animal kingdom.In the vertebrate lineage, deuterostomes like sea urchins and tunicates express proteins that arehomologues of C3, the central component of the ...
SV Nair, A Ramsden, DA Raftos
doaj  

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

New structural motifs on the chymotrypsin fold and their potential roles in complement factor B [PDF]

, 2000
Jing Hua, Yuanyuan Xu, Mike Carson, Dwight Moore, Kevin Macon, John E. Volanakis, Sthanam V.L. Narayana   +6 more
openalex   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Characterization of IFN-γ regulation of the complement factor B gene in macrophages [PDF]

, 2001
Yong Huang, Peter M. Krein, Brent W. Winston   +2 more
openalex   +1 more source