Factor B, the complement alternative pathway serine proteinase, is a major constitutive protein synthesized and secreted by resident and elicited mouse macrophages. [PDF]
, 1985 John S. Sundsmo +4 more
openalex +1 more source
MIF as an oncogenic driver of low‐heterogeneity melanomas
Molecular Oncology, EarlyView.Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran +4 more
wiley +1 more source
Groups in which every Lagrange subset is a factor [PDF]
arXivWe determine the finite groups $G$ in which every subset $A \subseteq G$ of cardinality dividing the order of $G$ is a \emph{factor}, i.e. has a complement $B \subseteq G$ of cardinality $|G|/|A|$ such that $G = A \cdot B$ or $G = B \cdot A$.
arxiv
Amino acid sequence of the Bb fragment from human complement Factor B. Alignment of the cyanogen bromide-cleavage peptides [PDF]
, 1983 Jean Gagnon, David L. Christie
openalex +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway. [PDF]
Int J Mol Sci, 2021 Murray H, Qiu B, Ho SY, Wang X.
europepmc +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
The Boolean intervals of Chevalley type are strongly non group-complemented [PDF]
arXiv, 2019 Let G be a finite Chevalley group and B a Borel subgroup. Then the interval [B,G] in L(G) is Boolean. We prove, using Zsigmondy's theorem, that for any element P in the open interval (B,G), its lattice-complement P^c is not a group-complement.
arxiv
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
Genericity and Universality for Operator Ideals [PDF]
arXiv, 2017 A bounded linear operator $U$ between Banach spaces is universal for the complement of some operator ideal $\mathfrak{J}$ if it is a member of the complement and it factors through every element of the complement of $\mathfrak{J}$. In the first part of this paper, we produce new universal operators for the complements of several ideals and give ...
arxiv