Results 211 to 220 of about 1,348,900 (304)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Antiinflammatory effects of polypeptide growth factors. Platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor inhibit the cytokine-induced expression of the alternative complement pathway activator factor B in human fibroblasts.

, 1990
Antonella Circolo, Glenn F. Pierce, Yitzhak Katz, Robert C. Strunk   +3 more
openalex   +1 more source

Adipose tissue complement factor B promotes adipocyte maturation

Adipose tissue complement factor B promotes adipocyte maturation
OBJECTIVES:It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters.
openaire  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration [PDF]

, 2007
Kylee L. Spencer, Michael A. Hauser, Lana M. Olson, Silke Schmidt, William K. Scott, Paul J. Gallins, Anita Agarwal, Eric A. Postel, Margaret A. Pericak‐Vance, Jonathan L. Haines   +9 more
openalex   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1 [PDF]

, 2016
Ming Wu, Meihan Chen, Ying Jing, Junhui Gu, Shuqin Mei, Qing Yao, Jie Zhou, Ming Yang, Lijun Sun, Wutao Wang, Huimin Hu, Rudolf P. Wüthrich, Changlin Mei   +12 more
openalex   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

The same human complement factor B allele of major histocompatibility complex (MHC) class III allele is conserved in chimpanzee and gorilla, stressing its immune importance

Antonio Arnaiz‐Villena, Christian Vaquero‐Yuste, Ignacio Juárez, José Manuel Martín‐Villa, Fabio Suárez‐Trujillo   +4 more
openalex   +1 more source