Results 241 to 250 of about 1,344,365 (268)

Detection of Complement Factor B Autoantibodies by ELISA

2021
Antibodies to autoantigens are implicated in a large number of diseases. Such autoantibodies may cause pathological activation of complement, an ancient humoral recognition and effector system of innate immunity; in addition, complement components or regulators may be target of autoantibodies and cause abnormal complement activation or function ...
Mihály, Józsi, Barbara, Uzonyi
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Deficiency in Complement Factor B

New England Journal of Medicine, 2013
A genetic deficiency of factor B confirms the role of the protein in the activation of the alternative complement pathway in humans and in protection against infection by encapsulated bacteria.
Charlotte Slade, Julian Bosco, Gary Unglik, Karl Bleasel, Mato Nagel, Ingrid Winship   +5 more
openaire   +1 more source

Molecular characterization of human complement factor B subtypes

Immunogenetics, 1990
While several laboratories have agreed that there are two subtypes of the BF*F alleles, no information has been available until now at the molecular level. The region of the BF gene corresponding to the Ba fragment [1.7 kilobases (kb)] of the BF*S, BF*FA, and BF*FB alleles has been sequenced after specific amplification using the polymerase chain ...
C, Davrinche, M, Abbal, A, Clerc
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Reference Typing Report for Complement Factor B

Experimental and Clinical Immunogenetics, 1998
Factor B (BF) reference typing was carried out on the occasion of the VIIth Complement Genetics Workshop in Mainz, May 1998. Two different sets of samples were analysed by agarose electrophoresis and/or isoelectric focusing at the protein level, and by PCR-RFLP analysis at the DNA level.
G. Geserick, P. Otremba, H. Schröder, B. Stradmann-Bellinghausen, P.M. Schneider   +4 more
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Cloning and sequencing of the porcine complement factor B

Immunogenetics, 1991
A genomic clone, SSBf1, containing the complement factor B (BF), a major histocompatibility class III antigen, has been isolated from a porcine genomic library. Partial sequencing and comparison with a human BF gene has identified seven exons coding for amino acids of Ba and Bb, the two subunits of BF.
L J, Peelman, A R, Van de Weghe, W R, Coppieters, A J, Van Zeveren, Y H, Bouquet   +4 more
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Hormonal Regulation of Complement Factor B in Human Endometrium

American Journal of Reproductive Immunology, 1993
PROBLEM: Recent investigations have demonstrated the presence of complement components in human endometrium in a cycle‐specific manner. Luteal phase endometrium has been shown to synthesize complement C3 de novo, whereas proliferative endometrium produces little or no C3. Likewise factor B. which is critical to the activation of the alternative pathway
L A, Hasty, W W, Brockman, J D, Lambris, C R, Lyttle   +3 more
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Analysis of complement Factor B activation by PAGE-immunoblotting

Journal of Immunological Methods, 1989
Initiation of complement activation via the alternative pathway results in cleavage of Factor B into two fragments Ba and Bb. Employing PAGE and immunoblotting analysis we have demonstrated Ba and Bb activation fragments following in vitro and in vivo activation in a range of biological fluids including cerebrospinal fluid and synovial fluid ...
M, Doran, D J, Reen
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Complement factor H and factor B expression in RPE cells

Acta Ophthalmologica, 2008
Abstract Purpose Age‐related macular degeneration (AMD) is the leading cause of untreatable blindness in the developed world. The pathogenesis of AMD is not fully understood. Recent evidence suggests that local inflammation in particular complement activation plays an important role. We aim to understand how complement activation is regulated at retina/
H XU, M CHEN, JV FORRESTER
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A New Complement Factor B Variant (BF S075) in Japanese

Human Heredity, 1990
A new slow-moving variant of the complement factor B, named BF S075, was found in a Japanese patient with cerebral thrombosis and urticaria. The variant was inherited in a codominant manner. The protein concentration and functional hemolytic activity of the complement factor B in the patient's serum were within normal limits.
H, Nishimukai, I, Maruyama, S, Takenaga, H, Kitamura, K, Mizutani, T, Shinomiya   +5 more
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Studies on esterolytic activity of alternative complement component factor B

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983
Abstract Alternative complement component factor B was purified from human plasma and its esterolytic activity on various α-naphthylester derivatives was examined. Of these substrates, LeuAlaArg-naphthylester was the most susceptible. The K m value of factor B for this substrate was about 5·10 −4 M.
N, Ikari, Y, Hitomi, M, Niinobe, S, Fujii   +3 more
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