Results 251 to 260 of about 1,344,365 (268)
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Factor B of the Alternative Complement Pathway on Human Lymphocytes
Scandinavian Journal of Immunology, 1976A factor on human lymphocytes has been identified as factor B of the alternative pathway. Lymphocytes can replace factor B in the fluid phase formation of C3 convertase with cobra venom factor (CVF). This lymphocyte activity is inhibited by specific anti‐human factor B, and it is shown by Burkitt lymphoma cell lines cultured in the absence of any ...
L, Halbwachs, P J, Lachmann
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DNA methylation and the origin of complement factor B polymorphism
Human Immunology, 1995BF is a polymorphic complement component encoded in the MHC. In each of two frequent alleles of BF, BF*FA and BF*FB, the difference in relation to the major allele BF*S has been shown to consist in the nonsynonymous substitution of only one base of the coding sequence.
J E, Mejía, I, Jahn, G, Hauptmann
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Molecular Basis for the Microheterogeneity of Human Complement Factor B
Complement, 1988The involvement of sialic acids in the microheterogeneity of human complement factor B was investigated. Desialylation kinetics revealed all the charge intermediates from a complex native to a homogeneous form. The relation between this heterogeneity and posttranslational events was explored in cultured hepatoma cells.
G, Garnier +3 more
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Complement factor B and the alternative pathway of complement activation in bovine milk
Journal of Dairy Research, 2002The contribution of the alternative pathway of complement activation to the capacity of normal milk to deposit C3 fragments on bacteria was tested by attempting to block C3 deposition with antibodies to the alternative pathway component factor B (fB).
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Duplication of the MHC-linked Xenopus complement factor B gene
Immunogenetics, 1995We have previously reported the molecular cloning of the mammalian major histocompatibility complex (MHC) class III gene, complement factor B (Bf) from Xenopus laevis, and linkage of the gene to the frog MHC. Here, we estimated the copy number of the Xenopus Bf gene by genomic Southern blotting analysis and demonstrated that Xenopus laevis has two ...
Y, Kato +5 more
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Quantitative differences between complement factor-B phenotypes.
Immunology, 1981In a study of 365 unrelated blood donors the structural polymorphism was determined by high-voltage electrophoresis followed by immunofixation with monospecific anti-Bf serum as described by Alper, Boenish & Watson (1972), and serum levels were measured by rocket-immunoelectrophoresis as described by Sjöholm (1975).
J P, Mortensen, L U, Lamm
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Structure and activation of complement components C2 and Factor B
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1984The activation of complement is initiated by two independent pathways. Each leads to the formation of a complex protease, C3 convertase, with equivalent specificity and function but different composition. The convertase derived from the classical pathway is composed of complement components C4 and C2 while that from the alternative pathway consists of ...
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The Ba fragment of complement factor B inhibits human B lymphocyte proliferation.
The Journal of Immunology, 1990Abstract Normal human B lymphocyte function is finely regulated by both positive and negative signals at each stage of activation, proliferation, and differentiation. Activation signals include antigen and surface Ig cross-linking agents such as anti-mu or anti-delta.
J L, Ambrus +3 more
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Antisense therapy targeting complement factor B
Molecular Immunology, 2018Tamar Grossman +7 more
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Rapid determination of the human complement factor B phenotypes.
Haematologia, 1989A rapid phenotyping method for human complement factor B (Bf) was worked out using high voltage acetate electrophoresis. The results were compared with those obtained by conventional agarose gel electrophoresis. Separation of the bands was performed in the same way, but only 2.5 hours were required for the evaluation of 24 samples.
J, Kramer, E, Thiry, G, Füst
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