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Case Report: Possible C3 nephritic factor-driven complement-mediated severe hemolytic anemia and acute kidney injury in a child with <i>Bordetella parapertussis</i> infection. [PDF]

open access: yesFront Immunol
Thorsen SU   +11 more
europepmc   +1 more source
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Complement component factor B has thrombin-like activity

Biochemical and Biophysical Research Communications, 2021
Serine proteases are fundamental components of biology, including innate immunity, which is systematically orchestrated in an orderly, balanced fashion in the healthy host. Such serine proteases are found in two well-recognized pathways of an innate immune network, coagulation and complement.
Kazue Takahashi   +3 more
openaire   +2 more sources

Detection of Complement Factor B Autoantibodies by ELISA

2021
Antibodies to autoantigens are implicated in a large number of diseases. Such autoantibodies may cause pathological activation of complement, an ancient humoral recognition and effector system of innate immunity; in addition, complement components or regulators may be target of autoantibodies and cause abnormal complement activation or function ...
Mihály, Józsi, Barbara, Uzonyi
openaire   +2 more sources

Deficiency in Complement Factor B

New England Journal of Medicine, 2013
A genetic deficiency of factor B confirms the role of the protein in the activation of the alternative complement pathway in humans and in protection against infection by encapsulated bacteria.
Charlotte Slade   +5 more
openaire   +1 more source

Molecular characterization of human complement factor B subtypes

Immunogenetics, 1990
While several laboratories have agreed that there are two subtypes of the BF*F alleles, no information has been available until now at the molecular level. The region of the BF gene corresponding to the Ba fragment [1.7 kilobases (kb)] of the BF*S, BF*FA, and BF*FB alleles has been sequenced after specific amplification using the polymerase chain ...
C, Davrinche, M, Abbal, A, Clerc
openaire   +2 more sources

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