Anti-factor B autoantibody in dense deposit disease [PDF]
, 2010 Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis type II, is a rare kidney disorder that is associated with dysregulation of the alternative pathway of complement.
Józsi, Mihály +4 more
core +1 more source
Frontiers in Microbiology, 2015 The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e. rough
Rauna eRiva +2 more
doaj +1 more source
The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. [PDF]
PLoS ONE, 2014 Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this ...
Rui Ma +9 more
doaj +1 more source
Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model. [PDF]
Front Immunol, 2019 Introduction: The majority of kidneys used for transplantation are retrieved from brain-dead organ donors. In brain death, the irreversible loss of brain functions results in hemodynamic instability, hormonal changes and immunological activation ...
Jager NM +7 more
europepmc +2 more sources
Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. [PDF]
PLoS One, 2017 The pathophysiology of myocardial injury that results from cardiac ischemia and reperfusion (I/R) is incompletely understood. Experimental evidence from murine models indicates that innate immune mechanisms including complement activation via the ...
Chun N +20 more
europepmc +2 more sources
Characterization of the sheep Complement Factor B gene (CFB) [PDF]
Veterinary Immunology and Immunopathology, 2011 The Complement Factor B gene (CFB) of the alternative complement pathway has been identified in the sheep Major Histocompatibility Complex (MHC) and its genomic sequence determined. CFB is located approximately 600 bp upstream of the complement C2 gene, contains 18 exons, and manifests the domain signature characteristic of CFB protein. Thirteen single
Qin, J +4 more
openaire +3 more sources
Atypical hemolytic uremic syndrome : update on the complement system and what is new [PDF]
, 2010 Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and predominant renal impairment. It is characterized by the absence of Shiga toxin-producing bacteria as a triggering factor.
Dickenmann, Michael +2 more
core +1 more source
Association between systemic complement levels and choroidal thickness in advanced non-neovascular age-related macular degeneration. [PDF]
Sci RepTo investigate associations between systemic complement activation and choroidal thickness (CT) in advanced non-neovascular age-related macular degeneration (nnAMD).
E de Carlo Forest T +12 more
europepmc +2 more sources
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]
, 2012 Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core +1 more source
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production
Frontiers in Immunology, 2019 Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity.
Máté G. Kiss +16 more
doaj +1 more source