Results 31 to 40 of about 2,034,857 (344)

Case Report: Combined Liver-Kidney Transplantation to Correct a Mutation in Complement Factor B in an Atypical Hemolytic Uremic Syndrome Patient. [PDF]

Front Immunol, 2021
López-Trascasa M, Alonso-Melgar Á, Melgosa-Hijosa M, Espinosa-Román L, Lledín-Barbancho MD, García-Fernández E, Rodríguez de Córdoba S, Sánchez-Corral P.   +7 more
europepmc   +3 more sources

Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen

Immunobiology
An over-active alternative complement pathway has been implicated in the pathophysiology of multiple diseases, including IgA nephropathy and geographic atrophy secondary to age related macular degeneration.
Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice   +10 more
doaj   +2 more sources

Complement Factor B Deficiency Is Dispensable for Female Fertility but Affects Microbiome Diversity and Complement Activity. [PDF]

Int J Mol Sci
Sunamoto M, Morohoshi K, Sato B, Mihashi R, Inui M, Yamada M, Miyado K, Kawano N.   +7 more
europepmc   +2 more sources

Factor H preserves alternative complement function during ARDS, linked to improved survival

ERJ Open Research, 2023
Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain, Mohammadreza Tabary, Sara R. Moore, Xiaojing An, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Viviana P. Ferreira, Janet S. Lee, S. Mehdi Nouraie   +11 more
doaj   +1 more source

The human complement factor B-C3b complex: Investigation of the interaction using C3b bound to thiol-Sepharose [PDF]

Williams S, Pondman K, Varghese PM, Aiyan AA, Kishore U, Sim RB.   +5 more
europepmc   +2 more sources

THE ROLE OF HUMAN COMPLEMENT PROTEIN FACTOR B AND FACTORP/PROPERDIN IN HIV-ASSOCIATED PRE-ECLAMPSIA

Hypertension in Pregnancy, 2022
Objectives This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE. Methods This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B
Phumelele Kikine, Yazira Pillay, Thajasvarie Naicker   +2 more
doaj   +1 more source

The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure

Frontiers in Immunology, 2021
ObjectiveDysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these ...
Margrethe Flesvig Holt, Margrethe Flesvig Holt, Annika E. Michelsen, Annika E. Michelsen, Negar Shahini, Elisabeth Bjørkelund, Christina Holt Bendz, Richard J. Massey, Richard J. Massey, Camilla Schjalm, Bente Halvorsen, Bente Halvorsen, Kaspar Broch, Kaspar Broch, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Per H. Nilsson, Per H. Nilsson, Pål Aukrust, Pål Aukrust, Pål Aukrust, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Mieke C. Louwe   +29 more
doaj   +1 more source

A new complement factor B mutation associated with crescentic C3 glomerulopathy; a case report [PDF]

Journal of Nephropathology, 2019
Background: C3 glomerulopathy is a recently described entity classified as complementassociated glomerular disease. Case Presentation: We report a case of a 48-year-old man referred to the nephrology department for nephrotic syndrome with rapidly ...
Sofia Semedo Coelho, Ana Raquel Fernandes, Elsa Soares, Patrícia Valério, Bruno Matos, Helena Romão, Mário Góis, Helena Sousa, Teresa Fidalgo, Ana Sofia Natário, Carlos Barreto   +10 more
doaj   +1 more source

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients

Cells, 2023
Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin   +3 more
doaj   +1 more source

Association of elevated levels of peripheral complement components with cortical thinning and impaired logical memory in drug-naïve patients with first-episode schizophrenia

Schizophrenia, 2023
Schizophrenia has been linked to polymorphism in genes encoding components of the complement system, and hyperactive complement activity has been linked to immune dysfunction in schizophrenia patients.
Hua Yu, Peiyan Ni, Yang Tian, Liansheng Zhao, Mingli Li, Xiaojing Li, Wei Wei, Jinxue Wei, Qiang Wang, Wanjun Guo, Wei Deng, Xiaohong Ma, Jeremy Coid, Tao Li   +13 more
doaj   +1 more source