Results 41 to 50 of about 367,967 (298)

Immune Evasion Strategies of Relapsing Fever Spirochetes

Frontiers in Immunology, 2020
Relapsing fever (RF) is claimed a neglected arthropod-borne disease caused by a number of diverse human pathogenic Borrelia (B.) species. These RF borreliae are separated into the groups of tick-transmitted species including B. duttonii, B.
Florian Röttgerding, Peter Kraiczy
doaj   +1 more source

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity. [PDF]

PLoS ONE, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Peter Kraiczy, Peter F Zipfel, Markus M Simon, Reinhard Wallich   +7 more
doaj   +1 more source

High Expression of Complement Components in the Kidneys of Type 2 Diabetic Rats With Diabetic Nephropathy

Frontiers in Endocrinology, 2019
Background: Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidneys; however, its pathogenesis remains unknown. This study assessed the expression of complement components in the kidneys of rats with type 2 DN to investigate ...
Yinqiong Huang, Jinting Xu, Xiaohong Wu, Xiaoyu Chen, Xuefeng Bai, Yong Zhuang, Jingwen Fang, Xiahong Lin   +7 more
doaj   +1 more source

Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report

Frontiers in Genetics, 2021
Complement factor B (CFB) variants have been described to play a causative role in auto-immune associated C3 glomerulopathy (C3G) and/or atypical hemolytic uremic syndrome (aHUS) by affecting the dysregulations of alternative pathway activation. However,
Feng-mei Wang, Yan Yang, Xiao-liang Zhang, Yan-li Wang, Yan Tu, Bi-Cheng Liu, Bin Wang   +6 more
doaj   +1 more source

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties

Scientific Reports, 2017
Borrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance.
Florian Röttgerding, Alex Wagemakers, Joris Koetsveld, Volker Fingerle, Michael Kirschfink, Joppe W. Hovius, Peter F. Zipfel, Reinhard Wallich, Peter Kraiczy   +8 more
doaj   +1 more source

Interrelationship between Porphyromonas gingivalis and complement C3 and factor B Levels in chronic periodontitis individuals

Dentistry and Medical Research, 2019
Background: To evaluate the effect of nonsurgical periodontal therapy on gingival crevicular fluid (GCF) and serum levels of complement C3 and factor B and their correlation with Porphyromonas gingivalis levels in chronic periodontitis (CP) individuals ...
Srirangarajan Sridharan, Paruchuri M Sravani   +1 more
doaj   +1 more source

Mice Deficient for the Complement Factor B Develop and Reproduce Normally [PDF]

Scandinavian Journal of Immunology, 1998
Factor B is an essential component of the complement cascade which forms the C3 and C5 convertase of the alternative pathway. Factor B cleavage products also function as cofactors in antibody‐independent monocyte‐mediated cytotoxicity, macrophage spreading, plasminogen activation and proliferation of B lymphocytes. Several healthy kindreds heterozygous
Max Albert Hietala, Christer Betsholtz, Ann Katrin Nilsson, Marcela Pekna, C Lagerberg, Milos Pekny, A Landin   +6 more
openaire   +3 more sources

Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging

BMJ Open Ophthalmology, 2020
Objective Systemic activation of the complement system in intermediate age-related macular degeneration (AMD) is understudied. Moreover, links between the presence of reticular pseudodrusen (RPD) and systemic complement dysregulation have not been ...
Anne M Lynch, Alan G Palestine, Brandie D Wagner, Jennifer L Patnaik, Ashley A Frazier-Abel, Marc T Mathias, Frank S Siringo, Vernon Michael Holers, Naresh Mandava   +8 more
doaj   +1 more source

In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway

Frontiers in Immunology, 2023
IntroductionSeveral diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3.
Emma Ispasanie, Emma Ispasanie, Lukas Muri, Lukas Muri, Marc Schmid, Marc Schmid, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke   +12 more
doaj   +1 more source

occumb: An R package for site occupancy modeling of eDNA metabarcoding data

Population Ecology, EarlyView.
This study introduces a new R package, occumb, for the convenient application of site occupancy modeling using environmental DNA (eDNA) metabarcoding data. We outline a data analysis workflow, including data setup, model fitting, model assessment, and comparison of potential study settings based on model predictions, all of which can be performed using
Keiichi Fukaya, Yuta Hasebe
wiley   +1 more source