Results 41 to 50 of about 1,344,365 (268)

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity. [PDF]

PLoS ONE, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Peter Kraiczy, Peter F Zipfel, Markus M Simon, Reinhard Wallich   +7 more
doaj   +1 more source

Complement system biomarkers in first episode psychosis [PDF]

, 2019
Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta, Gaughran, Fiona, Kopczynska, Maja, Mondelli, Valeria, Morgan, B. Paul, Murray, Robin, O'Donovan, Michael, Touchard, Samuel, Zelek, Wioleta   +8 more
core   +2 more sources

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties

Scientific Reports, 2017
Borrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance.
Florian Röttgerding, Alex Wagemakers, Joris Koetsveld, Volker Fingerle, Michael Kirschfink, Joppe W. Hovius, Peter F. Zipfel, Reinhard Wallich, Peter Kraiczy   +8 more
doaj   +1 more source

Interrelationship between Porphyromonas gingivalis and complement C3 and factor B Levels in chronic periodontitis individuals

Dentistry and Medical Research, 2019
Background: To evaluate the effect of nonsurgical periodontal therapy on gingival crevicular fluid (GCF) and serum levels of complement C3 and factor B and their correlation with Porphyromonas gingivalis levels in chronic periodontitis (CP) individuals ...
Srirangarajan Sridharan, Paruchuri M Sravani   +1 more
doaj   +1 more source

Specific inhibition of complement activation significantly ameliorates autoimmune blistering disease in mice [PDF]

, 2018
Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).
B. Paul Morgan, Detlef Zillikens, Falk Nimmerjahn, Joshua M. Thurman, Jörg Köhl, Jörg Köhl, Misa Hirose, Ralf J. Ludwig, Sidonia Mihai, Sidonia Mihai, V. Michael Holers, Yi Wang   +11 more
core   +3 more sources

Factor B as a therapeutic target for the treatment of complement-mediated diseases

Frontiers in Immunology
The complement system, consisting of three initiating pathways—classical, lectin and alternative, is an important part of innate immunity. Dysregulation of the complement system is implicated in the pathogenesis of several autoimmune and inflammatory ...
David Kavanagh, Jonathan Barratt, Anna Schubart, Nicholas J. A. Webb, Matthias Meier, Fadi Fakhouri   +5 more
doaj   +1 more source

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

Frontiers in Immunology, 2017
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi, Ádám I. Csincsi, Zoltán Mezei, Anne Kopp, Mario Hebecker, Barbara Uzonyi, Mihály Józsi   +6 more
doaj   +1 more source

Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman, Bob Siegerink, Sophie Piper, Rusan Catar, Guido Moll, Gabriela Riemekasten, Harald Heidecke, Peter U. Heuschmann, Mitchell S. V. Elkind, Duska Dragun, Matthias Endres   +10 more
doaj   +1 more source

Measurement of |V_{ub}/V_{cb}| (and |V_{ub}|) in Exclusive Nonleptonic Decays, \bar{B}^0 --> D_s^{(*)-}(\pi^+,\rho^+) and \bar{B}^0 --> D_s^{(*)-}D^{(*)+}

, 2000
We have studied extracting $|\vub/\vcb|$ by calculating the ratios ${\cal B}(\bar{B}^0\to D_s^{(*)-}(\pi^+,\rho^+))/{\cal B}(\bar{B}^0\to D_s^{(*)-}D^{(*)+})$ including penguin effects within the factorization assumption.
Kim, C. S., Kwon, Y., Lee, Jake, Namgung, W.   +3 more
core   +1 more source

Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report

Frontiers in Genetics, 2021
Complement factor B (CFB) variants have been described to play a causative role in auto-immune associated C3 glomerulopathy (C3G) and/or atypical hemolytic uremic syndrome (aHUS) by affecting the dysregulations of alternative pathway activation. However,
Feng-mei Wang, Yan Yang, Xiao-liang Zhang, Yan-li Wang, Yan Tu, Bi-Cheng Liu, Bin Wang   +6 more
doaj   +1 more source