Results 41 to 50 of about 1,348,900 (304)

Systemic complement activation in age-related macular degeneration. [PDF]

PLoS ONE, 2008
Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of
Hendrik P N Scholl, Peter Charbel Issa, Maja Walier, Stefanie Janzer, Beatrix Pollok-Kopp, Florian Börncke, Lars G Fritsche, Ngaihang V Chong, Rolf Fimmers, Thomas Wienker, Frank G Holz, Bernhard H F Weber, Martin Oppermann   +12 more
doaj   +1 more source

Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. [PDF]

, 2014
The alternative pathway of complement is implicated in the pathogenesis of several renal diseases, such as atypical hemolytic uremic syndrome, dense deposit disease and other forms of C3 glomerulopathy.
Józsi, Mihály, Lopez-Trascasa, M., Nozal, P., Prohászka, Zoltán, Reuter, S., Sanchez-Corral, P., Uzonyi, Barbara   +6 more
core   +1 more source

Exploring the function of factor XIII free B subunit: Interactions with complement factors and a novel approach to identify potential binding partners

Research and Practice in Thrombosis and Haemostasis, 2022
Background The factor XIII (FXIII)‐B subunit has a critical function as a carrier protein to stabilize FXIII‐A in plasma and supply it to its main substrate, fibrinogen.
Bojun Li, Clément Bechtler, Lorenz Jenny, Daniel Ricklin, Verena Schroeder   +4 more
doaj   +1 more source

Solar Carbon Monoxide, Thermal Profiling, and the Abundances of C, O, and their Isotopes [PDF]

, 2006
A solar photospheric "thermal profiling" analysis is presented, exploiting the infrared rovibrational bands of carbon monoxide (CO) as observed with the McMath-Pierce Fourier transform spectrometer (FTS) at Kitt Peak, and from above the Earth's ...
Abrams M. C., Asplund M., Asplund M., Ayres T. R., Ayres T. R., Brault J. W., Christoph U. Keller, Claude Plymate, Harris M. J., Hure J. M., John T. L., Lambert D. L., Lucas R., Magain P., McNamara K. M., Noyes R. W., Peach G., Thomas R. Ayres, Tsuji T., Wiens R. C., Wiens R. C.   +20 more
core   +2 more sources

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. [PDF]

PLoS ONE, 2010
One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B. burgdorferi express up to five distinct complement regulator-acquiring surface proteins (CRASP) which ...
Corinna Siegel, Teresia Hallström, Christine Skerka, Hannes Eberhardt, Barbara Uzonyi, Tobias Beckhaus, Michael Karas, Reinhard Wallich, Brian Stevenson, Peter F Zipfel, Peter Kraiczy   +10 more
doaj   +1 more source

Auditory display of seismic data: On the use of experts' categorizations and verbal descriptions as heuristics for geoscience [PDF]

, 2017
International audienceAuditory display can complement visual representations in order to better interpret scientific data. A previous article showed that the free categorization of “audified seismic signals” operated by listeners can be explained by ...
Boschi, Lapo, Dubois, Dani\ue8le, Holtzman, Benjamin, Le Carrou, Jean-Lo\uefc, Pat\ue9, Arthur   +4 more
core   +3 more sources

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]

PLoS Neglected Tropical Diseases, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Markus M Simon, Reinhard Wallich   +5 more
doaj   +1 more source

Cervicovaginal Complement Activation and Microbiota During Pregnancy and in Parturition

Frontiers in Immunology, 2022
BackgroundVaginal microbiome and the local innate immune defense, including the complement system, contribute to anti- and proinflammatory homeostasis during pregnancy and parturition.
Sivan Livson, Sivan Livson, Seppo Virtanen, Seppo Virtanen, A. Inkeri Lokki, A. Inkeri Lokki, Tiina Holster, Leena Rahkonen, Ilkka Kalliala, Ilkka Kalliala, Ilkka Kalliala, Pekka Nieminen, Pekka Nieminen, Anne Salonen, Seppo Meri, Seppo Meri   +15 more
doaj   +1 more source

Complement system biomarkers in first episode psychosis [PDF]

, 2019
Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta, Gaughran, Fiona, Kopczynska, Maja, Mondelli, Valeria, Morgan, B. Paul, Murray, Robin, O'Donovan, Michael, Touchard, Samuel, Zelek, Wioleta   +8 more
core   +2 more sources

Immune Evasion Strategies of Relapsing Fever Spirochetes

Frontiers in Immunology, 2020
Relapsing fever (RF) is claimed a neglected arthropod-borne disease caused by a number of diverse human pathogenic Borrelia (B.) species. These RF borreliae are separated into the groups of tick-transmitted species including B. duttonii, B.
Florian Röttgerding, Peter Kraiczy
doaj   +1 more source