Research and Practice in Thrombosis and Haemostasis, 2022 Background The factor XIII (FXIII)‐B subunit has a critical function as a carrier protein to stabilize FXIII‐A in plasma and supply it to its main substrate, fibrinogen.
Bojun Li +4 more
doaj +1 more source
Regulated expression of complement factor B in the human kidney
Kidney International, 1996 We have previously demonstrated regulated expression of C3 in the proximal renal tubular epithelial cells of humans. To test the hypothesis that local alternative pathway complement activation could contribute to the tubulointerstitial component of chronic renal disease, we examined factor B gene expression in human kidneys.
Thomas R. Welch +3 more
openaire +3 more sources
Hypoglycemia-induced changes in complement pathways in type 2 diabetes
Atherosclerosis Plus, 2021 Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothesized
Abu Saleh Md Moin +6 more
doaj
Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. [PDF]
PLoS ONE, 2010 One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B. burgdorferi express up to five distinct complement regulator-acquiring surface proteins (CRASP) which ...
Corinna Siegel +10 more
doaj +1 more source
Factorization fits and the unitarity triangle in charmless two-body B decays [PDF]
Phys.Rev.D68:113005,2003, 2003 We present fits to charmless hadronic B decay data from the BaBar, Belle and Cleo experiments using two theoretical models: (i) the QCD factorization model of Beneke et al. and (ii) QCD factorization complemented with the so-called charming penguins of Ciuchini et al.
arxiv +1 more source
Identification of Complin, a Novel Complement Inhibitor that Targets Complement Proteins Factor B and C2 [PDF]
The Journal of Immunology, 2010 Abstract Complement factor B (fB) is a key constituent of the alternative pathway (AP). Its central role in causing inflammation and tissue injury through activation of the AP urges the need for its therapeutic targeting. In the current study, we have screened phage-displayed random peptide libraries against fB and identified a novel ...
Arvind Sahu, Archana P. Kadam
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Profiling the Enzymatic Properties and Inhibition of Human Complement Factor B [PDF]
Journal of Biological Chemistry, 2007 Human complement factor B is the crucial catalytic component of the C3 convertase enzyme that activates the alternative pathway of complement-mediated immunity. Although a serine protease in its own right, factor B circulates in human serum as an inactive zymogen and there is a crystal structure only for the inactive state of factor B and various ...
Le, G. T, Abbenante, G., Fairlie, D. P
openaire +4 more sources
Familial C3 glomerulonephritis associated with mutations in the gene for complement factor B.
Nephrology, Dialysis and Transplantation, 2015 We report the first case of familial C3 glomerulonephritis (C3GN) associated with mutations in the gene for complement factor B (CFB). A 12-year-old girl was diagnosed with biopsy-proven C3GN.
Hideaki Imamura +7 more
semanticscholar +1 more source
Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]
PLoS Neglected Tropical Diseases, 2010 The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky +5 more
doaj +1 more source
Cervicovaginal Complement Activation and Microbiota During Pregnancy and in Parturition
Frontiers in Immunology, 2022 BackgroundVaginal microbiome and the local innate immune defense, including the complement system, contribute to anti- and proinflammatory homeostasis during pregnancy and parturition.
Sivan Livson +15 more
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