Results 51 to 60 of about 1,348,900 (304)

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties

Scientific Reports, 2017
Borrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance.
Florian Röttgerding, Alex Wagemakers, Joris Koetsveld, Volker Fingerle, Michael Kirschfink, Joppe W. Hovius, Peter F. Zipfel, Reinhard Wallich, Peter Kraiczy   +8 more
doaj   +1 more source

Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman, Bob Siegerink, Sophie Piper, Rusan Catar, Guido Moll, Gabriela Riemekasten, Harald Heidecke, Peter U. Heuschmann, Mitchell S. V. Elkind, Duska Dragun, Matthias Endres   +10 more
doaj   +1 more source

Measurement of |V_{ub}/V_{cb}| (and |V_{ub}|) in Exclusive Nonleptonic Decays, \bar{B}^0 --> D_s^{(*)-}(\pi^+,\rho^+) and \bar{B}^0 --> D_s^{(*)-}D^{(*)+}

, 2000
We have studied extracting $|\vub/\vcb|$ by calculating the ratios ${\cal B}(\bar{B}^0\to D_s^{(*)-}(\pi^+,\rho^+))/{\cal B}(\bar{B}^0\to D_s^{(*)-}D^{(*)+})$ including penguin effects within the factorization assumption.
Kim, C. S., Kwon, Y., Lee, Jake, Namgung, W.   +3 more
core   +1 more source

Factor B as a therapeutic target for the treatment of complement-mediated diseases

Frontiers in Immunology
The complement system, consisting of three initiating pathways—classical, lectin and alternative, is an important part of innate immunity. Dysregulation of the complement system is implicated in the pathogenesis of several autoimmune and inflammatory ...
David Kavanagh, Jonathan Barratt, Anna Schubart, Nicholas J. A. Webb, Matthias Meier, Fadi Fakhouri   +5 more
doaj   +1 more source

High Expression of Complement Components in the Kidneys of Type 2 Diabetic Rats With Diabetic Nephropathy

Frontiers in Endocrinology, 2019
Background: Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidneys; however, its pathogenesis remains unknown. This study assessed the expression of complement components in the kidneys of rats with type 2 DN to investigate ...
Yinqiong Huang, Jinting Xu, Xiaohong Wu, Xiaoyu Chen, Xuefeng Bai, Yong Zhuang, Jingwen Fang, Xiahong Lin   +7 more
doaj   +1 more source

Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report

Frontiers in Genetics, 2021
Complement factor B (CFB) variants have been described to play a causative role in auto-immune associated C3 glomerulopathy (C3G) and/or atypical hemolytic uremic syndrome (aHUS) by affecting the dysregulations of alternative pathway activation. However,
Feng-mei Wang, Yan Yang, Xiao-liang Zhang, Yan-li Wang, Yan Tu, Bi-Cheng Liu, Bin Wang   +6 more
doaj   +1 more source

Microbial neuraminidase induces a moderate and transient myelin vacuolation independent of complement system activation [PDF]

, 2017
Aims: Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA induces myelin vacuolation in axonal tracts.
Agamanolis, Banizs, Bergmann, Bergmann, Bhatia, Bhole, Blakemore, Brew, Briggs, Bugiani, Casarsa, Collins, Collins, Corfield, Costa, Crocker, DeMarco, Donin, Duncan, Dyer, Ellison, Francis, Fruttiger, Fujita, Fuvesi, Gomez-Roldan, Granados-Duran, Granados-Duran, Granados-Duran, Greco, Grondona, Howe, Hundgeburth, Isfort, Ji, Johannes, Jubb, Karnovsky, Kelm, Klamm, Klos, Kreutzberg, Kurosawa, Langone, Leenaerts, Liberski, Love, Love, Malik, Marie, Matalon, Mead, Mead, Nardone, Nataf, Ortiz-Hidalgo, Ozkale, Pangburn, Peckham, Pernet, Pérez-Martín, Quarles, Ramaglia, Rollins, Roscoe, Rother, Schmued, Schnaar, Seto, Shibuta, Sonmez, Stoop, Strenge, Sturgill, Stys, Susuki, Szalardy, Tegla, Trapp, Trapp, Trapp, Urich, Vakeva, van der Lugt, van der Lugt, van Dixhoorn, Voudris, Vyas, Walis, Webster, Wells, Wetsel, Yang   +92 more
core   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

The principal site of glycation of human complement factor B [PDF]

Biochemical Journal, 1991
Accumulating amino acid sequence data have made it increasingly evident that many essential complement proteins have potentially modifiable lysine residues in putative critical functional regions. Evidence is now presented that glucose is covalently attached to lysine-266 of purified human complement Factor B as a result of glycation.
M A, Niemann, A S, Bhown, E J, Miller
openaire   +2 more sources

Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen

Immunobiology
An over-active alternative complement pathway has been implicated in the pathophysiology of multiple diseases, including IgA nephropathy and geographic atrophy secondary to age related macular degeneration.
Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice   +10 more
doaj   +1 more source