Results 61 to 70 of about 2,034,857 (344)

Immune Evasion Strategies of Relapsing Fever Spirochetes

Frontiers in Immunology, 2020
Relapsing fever (RF) is claimed a neglected arthropod-borne disease caused by a number of diverse human pathogenic Borrelia (B.) species. These RF borreliae are separated into the groups of tick-transmitted species including B. duttonii, B.
Florian Röttgerding, Peter Kraiczy
doaj   +1 more source

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity. [PDF]

PLoS ONE, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Peter Kraiczy, Peter F Zipfel, Markus M Simon, Reinhard Wallich   +7 more
doaj   +1 more source

Mucosal Toll-like Receptor 3-dependent Synthesis of Complement Factor B and Systemic Complement Activation in Inflammatory Bowel Disease

Inflammatory Bowel Diseases, 2014
Background:Recent studies link Toll-like receptor 3 (TLR3) to the pathogenesis of inflammatory bowel disease (IBD). Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA (CFB) potently upregulated and ...
A. Østvik, A. Granlund, B. Gustafsson, S. Torp, T. Espevik, T. Mollnes, J. Damås, A. Sandvik   +7 more
semanticscholar   +1 more source

Measurement of |V_{ub}/V_{cb}| (and |V_{ub}|) in Exclusive Nonleptonic Decays, \bar{B}^0 --> D_s^{(*)-}(π^+,ρ^+) and \bar{B}^0 --> D_s^{(*)-}D^{(*)+} [PDF]

Phys.Rev.D63:094506,2001, 2000
We have studied extracting $|\vub/\vcb|$ by calculating the ratios ${\cal B}(\bar{B}^0\to D_s^{(*)-}(\pi^+,\rho^+))/{\cal B}(\bar{B}^0\to D_s^{(*)-}D^{(*)+})$ including penguin effects within the factorization assumption. The ratios involving $\bar{B}^0\to D_s^-D^{+}$ mode have considerable penguin corrections ($\sim 15%$ at the amplitude level), but ...
arxiv   +1 more source

Interrelationship between Porphyromonas gingivalis and complement C3 and factor B Levels in chronic periodontitis individuals

Dentistry and Medical Research, 2019
Background: To evaluate the effect of nonsurgical periodontal therapy on gingival crevicular fluid (GCF) and serum levels of complement C3 and factor B and their correlation with Porphyromonas gingivalis levels in chronic periodontitis (CP) individuals ...
Srirangarajan Sridharan, Paruchuri M Sravani   +1 more
doaj   +1 more source

Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report

Frontiers in Genetics, 2021
Complement factor B (CFB) variants have been described to play a causative role in auto-immune associated C3 glomerulopathy (C3G) and/or atypical hemolytic uremic syndrome (aHUS) by affecting the dysregulations of alternative pathway activation. However,
Feng-mei Wang, Yan Yang, Xiao-liang Zhang, Yan-li Wang, Yan Tu, Bi-Cheng Liu, Bin Wang   +6 more
doaj   +1 more source

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties

Scientific Reports, 2017
Borrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance.
Florian Röttgerding, Alex Wagemakers, Joris Koetsveld, Volker Fingerle, Michael Kirschfink, Joppe W. Hovius, Peter F. Zipfel, Reinhard Wallich, Peter Kraiczy   +8 more
doaj   +1 more source

High Expression of Complement Components in the Kidneys of Type 2 Diabetic Rats With Diabetic Nephropathy

Frontiers in Endocrinology, 2019
Background: Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidneys; however, its pathogenesis remains unknown. This study assessed the expression of complement components in the kidneys of rats with type 2 DN to investigate ...
Yinqiong Huang, Jinting Xu, Xiaohong Wu, Xiaoyu Chen, Xuefeng Bai, Yong Zhuang, Jingwen Fang, Xiahong Lin   +7 more
doaj   +1 more source

In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway

Frontiers in Immunology, 2023
IntroductionSeveral diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3.
Emma Ispasanie, Emma Ispasanie, Lukas Muri, Lukas Muri, Marc Schmid, Marc Schmid, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke   +12 more
doaj   +1 more source

Padé approximants to $B\toπ\ellν_{\ell}$ and $B_{s}\to K\ellν_{\ell}$ and determination of $|V_{ub}|$ [PDF]

, 2021
In light of the first observation of the semileptonic decay $B^{0}_{s}\to K^{-}\mu^{+}\nu_{\mu}$ by the LHCb collaboration, we revisit the determination of the CKM parameter $|V_{ub}|$ from exclusive semileptonic $B$-meson decays. A controlled theoretical input on the Standard Model $B\to\pi$ and $B_{s}\to K$ vector and scalar form factors from Lattice
arxiv   +1 more source