Results 61 to 70 of about 2,568,874 (328)
Identification of Complin, a Novel Complement Inhibitor that Targets Complement Proteins Factor B and C2 [PDF]
The Journal of Immunology, 2010 Abstract Complement factor B (fB) is a key constituent of the alternative pathway (AP). Its central role in causing inflammation and tissue injury through activation of the AP urges the need for its therapeutic targeting. In the current study, we have screened phage-displayed random peptide libraries against fB and identified a novel ...
Arvind Sahu, Archana P. Kadam
openaire +2 more sources
Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]
PLoS Neglected Tropical Diseases, 2010 The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky +5 more
doaj +1 more source
Cervicovaginal Complement Activation and Microbiota During Pregnancy and in Parturition
Frontiers in Immunology, 2022 BackgroundVaginal microbiome and the local innate immune defense, including the complement system, contribute to anti- and proinflammatory homeostasis during pregnancy and parturition.
Sivan Livson +15 more
doaj +1 more source
Profiling the Enzymatic Properties and Inhibition of Human Complement Factor B [PDF]
Journal of Biological Chemistry, 2007 Human complement factor B is the crucial catalytic component of the C3 convertase enzyme that activates the alternative pathway of complement-mediated immunity. Although a serine protease in its own right, factor B circulates in human serum as an inactive zymogen and there is a crystal structure only for the inactive state of factor B and various ...
Le, G. T, Abbenante, G., Fairlie, D. P
openaire +4 more sources
Auditory display of seismic data: On the use of experts' categorizations and verbal descriptions as heuristics for geoscience [PDF]
, 2017 International audienceAuditory display can complement visual representations in order to better interpret scientific data. A previous article showed that the free categorization of “audified seismic signals” operated by listeners can be explained by ...
Boschi, Lapo +4 more
core +2 more sources
Immune Evasion Strategies of Relapsing Fever Spirochetes
Frontiers in Immunology, 2020 Relapsing fever (RF) is claimed a neglected arthropod-borne disease caused by a number of diverse human pathogenic Borrelia (B.) species. These RF borreliae are separated into the groups of tick-transmitted species including B. duttonii, B.
Florian Röttgerding, Peter Kraiczy
doaj +1 more source
Dentistry and Medical Research, 2019 Background: To evaluate the effect of nonsurgical periodontal therapy on gingival crevicular fluid (GCF) and serum levels of complement C3 and factor B and their correlation with Porphyromonas gingivalis levels in chronic periodontitis (CP) individuals ...
Srirangarajan Sridharan +1 more
doaj +1 more source
Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman +10 more
doaj +1 more source
Complement system biomarkers in first episode psychosis [PDF]
, 2019 Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta +8 more
core +2 more sources
Scientific Reports, 2017 Borrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance.
Florian Röttgerding +8 more
doaj +1 more source