Results 71 to 80 of about 2,568,874 (328)

High Expression of Complement Components in the Kidneys of Type 2 Diabetic Rats With Diabetic Nephropathy

Frontiers in Endocrinology, 2019
Background: Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidneys; however, its pathogenesis remains unknown. This study assessed the expression of complement components in the kidneys of rats with type 2 DN to investigate ...
Yinqiong Huang, Jinting Xu, Xiaohong Wu, Xiaoyu Chen, Xuefeng Bai, Yong Zhuang, Jingwen Fang, Xiahong Lin   +7 more
doaj   +1 more source

Microbial neuraminidase induces a moderate and transient myelin vacuolation independent of complement system activation [PDF]

, 2017
Aims: Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA induces myelin vacuolation in axonal tracts.
Agamanolis, Banizs, Bergmann, Bergmann, Bhatia, Bhole, Blakemore, Brew, Briggs, Bugiani, Casarsa, Collins, Collins, Corfield, Costa, Crocker, DeMarco, Donin, Duncan, Dyer, Ellison, Francis, Fruttiger, Fujita, Fuvesi, Gomez-Roldan, Granados-Duran, Granados-Duran, Granados-Duran, Greco, Grondona, Howe, Hundgeburth, Isfort, Ji, Johannes, Jubb, Karnovsky, Kelm, Klamm, Klos, Kreutzberg, Kurosawa, Langone, Leenaerts, Liberski, Love, Love, Malik, Marie, Matalon, Mead, Mead, Nardone, Nataf, Ortiz-Hidalgo, Ozkale, Pangburn, Peckham, Pernet, Pérez-Martín, Quarles, Ramaglia, Rollins, Roscoe, Rother, Schmued, Schnaar, Seto, Shibuta, Sonmez, Stoop, Strenge, Sturgill, Stys, Susuki, Szalardy, Tegla, Trapp, Trapp, Trapp, Urich, Vakeva, van der Lugt, van der Lugt, van Dixhoorn, Voudris, Vyas, Walis, Webster, Wells, Wetsel, Yang   +92 more
core   +1 more source

In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway

Frontiers in Immunology, 2023
IntroductionSeveral diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3.
Emma Ispasanie, Emma Ispasanie, Lukas Muri, Lukas Muri, Marc Schmid, Marc Schmid, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke   +12 more
doaj   +1 more source

Mice Deficient for the Complement Factor B Develop and Reproduce Normally [PDF]

Scandinavian Journal of Immunology, 1998
Factor B is an essential component of the complement cascade which forms the C3 and C5 convertase of the alternative pathway. Factor B cleavage products also function as cofactors in antibody‐independent monocyte‐mediated cytotoxicity, macrophage spreading, plasminogen activation and proliferation of B lymphocytes. Several healthy kindreds heterozygous
Max Albert Hietala, Christer Betsholtz, Ann Katrin Nilsson, Marcela Pekna, C Lagerberg, Milos Pekny, A Landin   +6 more
openaire   +3 more sources

Measurement of |V_{ub}/V_{cb}| (and |V_{ub}|) in Exclusive Nonleptonic Decays, \bar{B}^0 --> D_s^{(*)-}(\pi^+,\rho^+) and \bar{B}^0 --> D_s^{(*)-}D^{(*)+}

, 2000
We have studied extracting $|\vub/\vcb|$ by calculating the ratios ${\cal B}(\bar{B}^0\to D_s^{(*)-}(\pi^+,\rho^+))/{\cal B}(\bar{B}^0\to D_s^{(*)-}D^{(*)+})$ including penguin effects within the factorization assumption.
Kim, C. S., Kwon, Y., Lee, Jake, Namgung, W.   +3 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

Frontiers in Immunology, 2017
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi, Ádám I. Csincsi, Zoltán Mezei, Anne Kopp, Mario Hebecker, Barbara Uzonyi, Mihály Józsi   +6 more
doaj   +1 more source

Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging

BMJ Open Ophthalmology, 2020
Objective Systemic activation of the complement system in intermediate age-related macular degeneration (AMD) is understudied. Moreover, links between the presence of reticular pseudodrusen (RPD) and systemic complement dysregulation have not been ...
Anne M Lynch, Alan G Palestine, Brandie D Wagner, Jennifer L Patnaik, Ashley A Frazier-Abel, Marc T Mathias, Frank S Siringo, Vernon Michael Holers, Naresh Mandava   +8 more
doaj   +1 more source

Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report

Frontiers in Genetics, 2021
Complement factor B (CFB) variants have been described to play a causative role in auto-immune associated C3 glomerulopathy (C3G) and/or atypical hemolytic uremic syndrome (aHUS) by affecting the dysregulations of alternative pathway activation. However,
Feng-mei Wang, Yan Yang, Xiao-liang Zhang, Yan-li Wang, Yan Tu, Bi-Cheng Liu, Bin Wang   +6 more
doaj   +1 more source

Retinol-binding protein 4 and its potential roles in hypercholesterolemia revealed by proteomics [PDF]

, 2015
Effects of hypercholesterolemia on alterations of serum proteins have not been fully elucidated. Herein, using two-dimensional gel electrophoresis (2-DE) in conjunction with LC-MS searching has successfully been carried out to investigate the change of ...
Isarankura-Na-Ayudhya, Chartchalerm, Isarankura-Na-Ayudhya, Patcharee, Jugnam-ang, Watcharapong, Lawung, Ratana, Pannengpetch, Supitcha, Prachayasittikul, Virapong, Thippakorn, Chadinee   +6 more
core   +1 more source