Results 71 to 80 of about 2,034,857 (344)

Mice Deficient for the Complement Factor B Develop and Reproduce Normally [PDF]

Scandinavian Journal of Immunology, 1998
Factor B is an essential component of the complement cascade which forms the C3 and C5 convertase of the alternative pathway. Factor B cleavage products also function as cofactors in antibody‐independent monocyte‐mediated cytotoxicity, macrophage spreading, plasminogen activation and proliferation of B lymphocytes. Several healthy kindreds heterozygous
Max Albert Hietala, Christer Betsholtz, Ann Katrin Nilsson, Marcela Pekna, C Lagerberg, Milos Pekny, A Landin   +6 more
openaire   +3 more sources

A Conserved Element in the Serine Protease Domain of Complement Factor B [PDF]

Journal of Biological Chemistry, 1998
Factor B and C2 are serine proteases that carry the catalytic sites of the complement C3 and C5 convertases. Their protease domains are activated by conformational changes that occur during convertase assembly and are deactivated upon convertase dissociation.
Lynne M. Mitchell, Dennis E. Hourcade, Teresa J. Oglesby   +2 more
openaire   +2 more sources

On fundamental groups related to the Hirzebruch surface F_1 [PDF]

, 2007
Given a projective surface and a generic projection to the plane, the braid monodromy factorization (and thus, the braid monodromy type) of the complement of its branch curve is one of the most important topological invariants, stable on deformations. From this factorization, one can compute the fundamental group of the complement of the branch curve ...
arxiv   +1 more source

Complement Factor B Is the Downstream Effector of TLRs and Plays an Important Role in a Mouse Model of Severe Sepsis

Journal of Immunology, 2013
Severe sepsis involves massive activation of the innate immune system and leads to high mortality. Previous studies have demonstrated that various types of TLRs mediate a systemic inflammatory response and contribute to organ injury and mortality in ...
Lin Zou, Yan Feng, Yan Li, Ming Zhang, Chan Chen, Jiayan Cai, Yu Gong, Larry L. Wang, J. Thurman, Xiaobo Wu, J. Atkinson, W. Chao   +11 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging

BMJ Open Ophthalmology, 2020
Objective Systemic activation of the complement system in intermediate age-related macular degeneration (AMD) is understudied. Moreover, links between the presence of reticular pseudodrusen (RPD) and systemic complement dysregulation have not been ...
Anne M Lynch, Alan G Palestine, Brandie D Wagner, Jennifer L Patnaik, Ashley A Frazier-Abel, Marc T Mathias, Frank S Siringo, Vernon Michael Holers, Naresh Mandava   +8 more
doaj   +1 more source

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma [PDF]

The American Journal of Pathology, 2017
Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-time quantitative PCR and Western ...
Markku Kallajoki, Pilvi Riihilä, Pilvi Riihilä, Atte Kivisaari, Atte Kivisaari, Seppo Meri, Liisa Nissinen, Liisa Nissinen, Veli-Matti Kähäri, Veli-Matti Kähäri, Juha Peltonen, Taina Pihlajaniemi, Ritva Heljasvaara, Ritva Heljasvaara, Reidar Grénman, Sirkku Peltonen, Mehdi Farshchian, Mehdi Farshchian   +17 more
openaire   +6 more sources

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022
One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen, Meng‐Meng Ji, Peng‐Peng Xu, Wei‐Li Zhao   +3 more
wiley   +1 more source

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

Frontiers in Immunology, 2017
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi, Ádám I. Csincsi, Zoltán Mezei, Anne Kopp, Mario Hebecker, Barbara Uzonyi, Mihály Józsi   +6 more
doaj   +1 more source