Results 91 to 100 of about 1,235,428 (322)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Functional Characterization of the Disease-Associated N-Terminal Complement Factor H Mutation W198R

Frontiers in Immunology, 2017
Dysregulation of the complement alternative pathway is involved in the pathogenesis of several diseases, including the kidney diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Marcell Cserhalmi, Barbara Uzonyi, Nicolas S. Merle, Dorottya Csuka, Edgar Meusburger, Karl Lhotta, Zoltán Prohászka, Zoltán Prohászka, Mihály Józsi   +8 more
doaj   +1 more source

A novel trifunctional IgG-like bispecific antibody to inhibit HIV-1 infection and enhance lysis of HIV by targeting activation of complement [PDF]

, 2010
BACKGROUND: The complement system is not only a key component of innate immunity but also provides a first line of defense against invading pathogens, especially for viral pathogens.
Chuanfu Zhang, Fei Qiao, Hongbin Song, Huihui Chong, Leili Jia, Ligui Wang, Shaofu Qiu, Stephen Tomlinson, Weijing Liu, Yansong Sun, Yanwei Zhong, Yong Wang, Yuanyong Xu, Yusen Zhou, Yuxian He   +14 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Factor H Cleavage by the Treponema denticola Protease Dentilisin: Understanding the Pathogenesis of Periodontal Disease [PDF]

, 2013
Periodontal disease is an infectious condition that results in the inflammation and gradual degradation of gum tissue and alveolar bone. Caused by plaque deposits on teeth that harden into tartar to inflame gum tissue, the condition is highly pervasive ...
Aggarwal, Sahil
core   +1 more source

Complement factor h-antibody-associated hemolytic uremic syndrome: pathogenesis, clinical presentation, and treatment. [PDF]

, 2014
The presence of circulating autoantibodies, primarily to complement factor H antibodies (CFH-Abs) in plasma characterizes the autoimmune form of atypical hemolytic uremic syndrome (aHUS).
Giner, T., Hofer, J., Józsi, Mihály
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring

Frontiers in Immunology
Fibroproliferative cutaneous pathologies such as hypertrophic scars and keloids have a high prevalence after burns and surgical interventions; however, their pathophysiology remains not fully understood.
Ilja L. Kruglikov, Katarzyna Walendzik, Philipp E. Scherer   +2 more
doaj   +1 more source

Localization of complement factor H gene expression and protein distribution in the mouse outer retina. [PDF]

, 2015
To determine the localization of complement factor H (Cfh) mRNA and its protein in the mouse outer retina.Quantitative real-time PCR (qPCR) was used to determine the expression of Cfh and Cfh-related (Cfhr) transcripts in the RPE/choroid.
Estep, Jason, Gong, Qizhi, Hjelmeland, Leonard M, Nguyen, Anthony T, Oltjen, Sharon L, Radu, Roxana A, Smit-McBride, Zeljka   +6 more
core   +1 more source

Complement factor H

, 2012
Complement factor H (fH) is a single chain plasma glycoprotein (approximately 150 kDa in size), with 20 domains termed complement control protein (CCP) domains or short consensus repeats (SCR). The complement factor H gene (CFH) is located on chromosome 1q32 in the regulators of complement activation (RCA) gene cluster, adjacent to the genes that code ...
Dinasarapu, Ashok Reddy, Chandrasekhar, Anjana, Jozsi, Mihaly, Subramaniam, Shankar   +3 more
openaire   +1 more source