Results 101 to 110 of about 2,568,825 (335)

Complement factor H in host defense and immune evasion

Cellular and Molecular Life Sciences, 2016
Complement is the major humoral component of the innate immune system. It recognizes pathogen- and damage-associated molecular patterns, and initiates the immune response in coordination with innate and adaptive immunity.
Raffaella Parente, Simon J. Clark, A. Inforzato, A. Day   +3 more
semanticscholar   +1 more source

Factor H-related proteins determine complement-activating surfaces [PDF]

Trends in Immunology, 2015
Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation. Because FHRs are evolutionarily and structurally related to complement inhibitor factor H (FH), the initial assumption was that the FHRs are also
Józsi, Mihály, Tortajada, A., Uzonyi, Barbara, Goicoechea de, Jorge E., Rodriguez de Cordoba, S.   +4 more
openaire   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Functional Characterization of the Disease-Associated N-Terminal Complement Factor H Mutation W198R

Frontiers in Immunology, 2017
Dysregulation of the complement alternative pathway is involved in the pathogenesis of several diseases, including the kidney diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Marcell Cserhalmi, Barbara Uzonyi, Nicolas S. Merle, Dorottya Csuka, Edgar Meusburger, Karl Lhotta, Zoltán Prohászka, Zoltán Prohászka, Mihály Józsi   +8 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. [PDF]

, 2013
The sub-retinal pigment epithelial deposits (sRPEds) that are a hallmark of age-related macular degeneration (AMD) contain both C3b and mM levels of zinc.
Gor, J, Lengyel, I, Nan, R, Pao, PJ, Perkins, SJ, Rodriguez, E, Tetchner, S   +6 more
core   +1 more source

Regulation of age-related macular degeneration-like pathology by complement factor H

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance Age-related macular degeneration (AMD) affects approximately one-third of Americans over 70 and is characterized by lipoprotein-rich sub-retinal pigmented epithelium (sub-RPE) deposits.
C. Toomey, Una Kelly, D. Saban, Catherine Bowes Rickman   +3 more
semanticscholar   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Complement depletion during haemofiltration with polyacrilonitrile membranes [PDF]

, 2017
Background Polyacrylonitrile (PAN, AN69®) dialysis membranes have been shown to improve the outcome of critically ill patients. Factor D is an essential enzyme of the alternative pathway of complement and is increased during renal failure.
Chevrolet, Jean-Claude, Favre, Hervé, Gasche, Yvan, Pascual, Manuel, Schifferli, Jürg A., Suter, Peter. M.   +5 more
core  

Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants

Scientific Reports, 2016
Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the ...
B. Molins, P. Fuentes-Prior, A. Adán, R. Antón, J. Aróstegui, J. Yagüe, A. Dick   +6 more
semanticscholar   +1 more source