Results 91 to 100 of about 2,568,825 (335)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Complement factor H gene polymorphisms and vivax malaria associated thrombotic microangiopathy

Saudi Journal of Kidney Diseases and Transplantation, 2019
Acute kidney injury (AKI) occurs in about 1% of cases of malaria; however, in these cases, the mortality rate can be as high as 45%. Thrombotic microangiopathy (TMA) as a cause of AKI in malaria is rare with only a handful cases documented in literature ...
Parimal Agrawal, Ashwani Kumar, Amber Parwaiz, Amit Rawat, Karalanglin Tiewsoh, Ritambhra Nada   +5 more
doaj   +1 more source

Hemorrhage-induced intestinal damage is complement independent in Helicobacter hepaticus infected mice [PDF]

, 2010
With over half of the world population infected, Helicobacter infection is an important public health issue associated with gastrointestinal cancers and inflammatory bowel disease.
Fleming, Sherry D., Hoffman, Sara M., Hylton, Diana J., Phillips, Lauren M.   +3 more
core   +1 more source

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age‐Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure

Stem Cells, 2017
Age‐related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors.
D. Hallam, J. Collin, S. Bojic, V. Chichagova, A. Buskin, Yaobo Xu, Lucia Lafage, Elsje G. Otten, G. Anyfantis, Carla B. Mellough, S. Przyborski, Sameer E. Alharthi, V. Korolchuk, A. Lotery, G. Saretzki, M. Mckibbin, L. Armstrong, D. Steel, D. Kavanagh, M. Lako   +19 more
semanticscholar   +1 more source

Polyanion-Induced Self-Association of Complement Factor H [PDF]

The Journal of Immunology, 2009
Abstract Factor H is the primary soluble regulator of activation of the alternative pathway of complement. It prevents activation of complement on host cells and tissues upon association with C3b and surface polyanions such as sialic acids, heparin, and other glycosaminoglycans.
Michael K, Pangburn, Nenoo, Rawal, Claudio, Cortes, M Nurul, Alam, Viviana P, Ferreira, Mark A L, Atkinson   +5 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Complement Factor H Polymorphism p.Tyr402His and Cuticular Drusen [PDF]

Archives of Ophthalmology, 2007
To determine the histidine frequency in patients with the cuticular drusen phenotype of age-related macular degeneration (AMD).Fifty individuals were identified who met the criteria for the cuticular drusen phenotype using a standard threshold photograph. We genotyped DNA samples using a polymerase chain reaction-based restriction digest assay.
Michael A, Grassi, James C, Folk, Todd E, Scheetz, Christine M, Taylor, Val C, Sheffield, Edwin M, Stone   +5 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Factor H-Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation. [PDF]

, 2015
The physiological roles of the factor H (FH)-related proteins are controversial and poorly understood. Based on genetic studies, FH-related protein 5 (CFHR5) is implicated in glomerular diseases, such as atypical hemolytic uremic syndrome, dense deposit
Bánlaki, Zsófia, Csincsi, Ádám, Józsi, Mihály, Kopp, Anne, Uzonyi, Barbara, Zöldi, Miklós   +5 more
core   +4 more sources

Anti-factor B autoantibody in dense deposit disease [PDF]

, 2010
Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis type II, is a rare kidney disorder that is associated with dysregulation of the alternative pathway of complement.
Józsi, Mihály, Papp, Krisztián, Prechl, József, Strobel, S., Zimmering, M.   +4 more
core   +1 more source