Results 121 to 130 of about 1,235,428 (322)

Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains [PDF]

, 2007
Matthew C. Pickering, Elena Goicoechea de Jorge, Rubén Martínez-Barricarte, Sergio Recalde, Alfredo García‐Layana, Kirsten L. Rose, Jill Moss, Mark Walport, H. Terence Cook, Santiago Rodrı́guez de Córdoba, Marina Botto   +10 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Interaction of Human Complement Factor H Variants Tyr402 and His 402 with Leptospira spp.

Frontiers in Immunology, 2011
Leptospirosis is a zoonosis caused by pathogenic bacteria from the genus Leptospira. The disease represents a serious public health problem in underdeveloped tropical countries.
Aldacilene Souza Silva, Mónica Marcela Castiblanco Valencia, Aurora Marques Cianciarullo, Silvio Arruda Vasconcellos, Angela Silva Barbosa, Lourdes eIsaac   +5 more
doaj   +1 more source

Complement Factor H is a Novel Biomarker for Diagnosis and Prognosis of Patients with Liver Cancer [PDF]

, 2022
Chao Lv, Qiqi Zhang, Chunyu Li, Yonggang Li, Enjiang Li, Z R Li, Timothy C. Wang   +6 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Factor H: A Complement Regulator in Health and Disease, and a Mediator of Cellular Interactions

Biomolecules, 2012
Complement is an essential part of innate immunity as it participates in host defense against infections, disposal of cellular debris and apoptotic cells, inflammatory processes and modulation of adaptive immune responses.
Mihály Józsi, Eliška Svobodová, Mario Hebecker, Anne Kopp   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Supplementary Figure Legends from Complement Factor H Antibodies from Lung Cancer Patients Induce Complement-Dependent Lysis of Tumor Cells, Suggesting a Novel Immunotherapeutic Strategy

, 2023
Michael J. Campa, Elizabeth B. Gottlin, Ryan T. Bushey, Edward F. Patz   +3 more
openalex   +1 more source

Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies [PDF]

, 2021
Gautier Bréville, Ido Zamberg, Salima Sadallah, Caroline Stephan, Belén Ponte, Jörg D. Seebach   +5 more
openalex   +1 more source