Results 171 to 180 of about 349,286 (299)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton. [PDF]

Commun Biol
Rezola Artero M, Minery A, Revel M, Armento A, Jarboui MA, Boudhabhay I, de Castro Deus M, Zarantonello A, Fleury E, Segarra L, Redissi A, Merle NS, Dragon-Durey MA, Monnot C, Sautes-Fridman C, Dimitrov JD, Fridman WH, Ueffing M, Roumenina LT.   +18 more
europepmc   +1 more source

Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation. [PDF]

EMBO Rep, 2023
Chernyaeva L, Ratti G, Teirilä L, Fudo S, Rankka U, Pelkonen A, Korhonen P, Leskinen K, Keskitalo S, Salokas K, Gkolfinopoulou C, Crompton KE, Javanainen M, Happonen L, Varjosalo M, Malm T, Leinonen V, Chroni A, Saavalainen P, Meri S, Kajander T, Wollman AJ, Nissilä E, Haapasalo K.   +23 more
europepmc   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Geographic Atrophy in Patients with Age-Related Macular Degeneration Is Associated with Rare Variants in Complement Factor H and Complement Factor I. [PDF]

Ophthalmol Sci
de Breuk A, de Jong S, Bakker B, Kersten E, Luttikhuizen DT, Fauser S, Klaver CCW, den Hollander AI, Hoyng CB, Lechanteur YTE.   +9 more
europepmc   +1 more source

Complement factor H inhibits endothelial cell migration through suppression of STAT3 signaling. [PDF]

Exp Ther Med, 2023
Li J, Huang H, Xu S, Fan M, Wang K, Wang X, Zhang J, Huang S, Gatt A, Liu J.   +9 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase [PDF]

, 1993
Estaller, C., Tobias Sokolowski, Cornelia Estaller, Birgit Lüttig, Dippold, W., Karl-Hermann Meyer zum Büschenfelde, Whaley, K., Keith Whaley, Wolfgang Dippold, Elisabeth H. Weiss, Schwaeble, W., Luttig, B., Meyer zum Buschenfelde, K. H., Weiss, Elisabeth H., Wilhelm Schwaeble, Sokolowski, T.   +15 more
core   +1 more source

Gene and protein profiling of Dickkopf-3 and complement factor H in periodontitis and coronary artery disease. [PDF]

Front Dent Med
Mahendra J, Maharavi B, Natarajan PM, Arumugam M.   +3 more
europepmc   +1 more source

Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism. [PDF]

Nat Commun, 2023
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schrottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Trégouët DA, Odeberg J.   +42 more
europepmc   +1 more source