Results 291 to 300 of about 2,568,825 (335)
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Anti-complement-factor H-associated glomerulopathies
Nature Reviews Nephrology, 2016Atypical haemolytic uraemic syndrome (aHUS), an important cause of acute kidney injury, is characterized by dysregulation of the complement pathway, frequent need for dialysis, and progression to end-stage renal disease. Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement ...
M. Durey +3 more
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Complement factor H: a guardian within?
Kidney International, 2021The glomerular endothelium produces the key complement regulator factor H (FH), but its role in the endothelial cells protection and functional integrity is unclear. In this edition of Kidney International, Mahajan et al. demonstrate that the endothelial-
I. Boudhabhay, L. Roumenina
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The Pleiotropy of Complement Factor H.
JAMA Ophthalmology, 2023E. Rossin, L. Sobrin
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Local Complement Factor H protects kidney endothelial cell structure and function.
Kidney International, 2021Factor H (FH) is a critical regulator of the alternative complement pathway and its deficiency or mutation underlie kidney diseases such as dense deposit disease.
S. Mahajan +7 more
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Functional Anatomy of Complement Factor H
Biochemistry, 2013Factor H (FH) is a soluble regulator of the proteolytic cascade at the core of the evolutionarily ancient vertebrate complement system. Although FH consists of a single chain of similar protein modules, it has a demanding job description. Its chief role is to prevent complement-mediated injury to healthy host cells and tissues. This entails recognition
Elisavet, Makou +2 more
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Complement regulator factor H in multiple sclerosis
Journal of Cellular Biochemistry, 2011A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients. We have previously demonstrated raised serum fH levels in MS and here, an extended analysis, quantifying fH ...
Gillian, Ingram +4 more
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Ancient Origin of Human Complement Factor H
Journal of Molecular Evolution, 1998We studied the evolutionary history of two homologous proteins of the human complement system, factor H (FH) and the alpha chain of the C4b binding protein (C4bpalpha), and included in this study the related proteins from the barred sand bass (P. nebulifer) and the nematode C. elegans. Phylogenetic trees inferred from individual short consensus repeats
J, Krushkal, C, Kemper, I, Gigli
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Sequence polymorphism of human complement factor H
Immunogenetics, 1988Factor H is a major regulatory protein of the complement system. The complete cDNA coding sequence has been derived from overlapping clones, and a polymorphism at base 1277 has been characterized. In four clones there is a T at nucleotide 1277 and in two others there is a C.
Day, Anthony J. +3 more
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Complement factor H and hemolytic uremic syndrome
International Immunopharmacology, 2001Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long.
Zipfel, Peter F. +6 more
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