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Urinary Complement Factor H in Renal Disease
Nephron, 2002<i>Background:</i> Complement factor H (hCFH) plays a key inhibitory role in the control of the alternative complement pathway. We examined whether urinary hCFH (U-hCFH) levels is useful as an indirect indicator of renal damage. <i>Methods:</i> Urine samples were obtained from 104 patients with renal disease. Urine was collected
Mariko, Tamano +5 more
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Elevated Complement Factor H Levels in Asthmatic Sputa
Journal of Clinical Immunology, 2012The alternative pathway of the complement system is known to play a role in the generation of asthmatic airway inflammation, but its regulatory complement protein, factor H has not been investigated in this disease.Our aim was to determine the local bronchial complement factor H (CFH) levels in asthma, and to investigate its relationship with ...
Weiszhár, Z. +7 more
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Ultrastructures and interactions of complement factors H and I
The Journal of Immunology, 1992Abstract The human complement regulatory protein, factor H, was examined by high resolution transmission electron microscopy. Results of electron microscopy confirm hydrodynamic analysis and indicate that factor H is a monomer of M(r) approximately 155,000.
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Staphylococcus disrupts complement activation
Nature Reviews Microbiology, 2021Grant Otto, Otto Grant
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A guide to complement biology, pathology and therapeutic opportunity
Nature Reviews Immunology, 2023Dimitrios C Mastellos +2 more
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Complosome — the intracellular complement system
Nature Reviews Nephrology, 2023Erin E West +2 more
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Clinical promise of next-generation complement therapeutics
Nature Reviews Drug Discovery, 2019Dimitrios C Mastellos +2 more
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