Results 261 to 270 of about 349,286 (299)

Complement Factor H: Physiology and Pathophysiology

Seminars in Thrombosis and Hemostasis, 2001
The human plasma protein factor H, which is a multifunctional, multidomain protein, acts as a central regulator of the complement system. In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3 ...
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The dysfunctions of complement factor H in lupus nephritis

Lupus, 2016
Objective Our previous study showed that plasma levels of factor H (FH) were significantly decreased in patients with lupus nephritis and reflected lupus nephritis activity. The aim of this study was to further investigate in vitro biofunctions of plasma FH in patients with lupus nephritis.
F-M, Wang, D, Song, Y, Pang, Y, Song, F, Yu, M-H, Zhao   +5 more
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Complement factor H and hemolytic uremic syndrome

International Immunopharmacology, 2001
Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long.
Zipfel, Peter F., Skerka, Christine, Caprioli, Jessica, Manuelian, Tamara, Neumann, Hartmut P. H., Noris, Marina, Remuzzi, Giuseppe   +6 more
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Genetic polymorphism of complement factor H in cattle

Animal Genetics, 1990
Summary Bovine factor H was found to be polymorphic by the combined techniques of SDS‐polyacrylamide electrophoresis of bovine plasma and immunoblotting. Three phenotypes (S, SF, F) were identified in a sample population of 149 cattle. Variant S and F differed by an apparent molecular weight of 5000 daltons.
H, Tabel, H J, Groat, G J, Kraay, W P, Aston   +3 more
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Complement factor H: a guardian within?

Kidney International, 2021
The glomerular endothelium produces the key complement regulator factor H (FH), but its role in the endothelial cells protection and functional integrity is unclear. In this edition of Kidney International, Mahajan et al. demonstrate that the endothelial-intrinsic FH is important for the cytoskeletal architecture, monolayer integrity, proliferation ...
Idris Boudhabhay, Lubka T. Roumenina
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Plasma Complement factor H in Alzheimer's Disease

Journal of Alzheimer's Disease, 2015
Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results.
Williams, Michael A., Haughton, David, Stevenson, Michael, Craig, David, Passmore, A. Peter, Silvestri, Giuliana   +5 more
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Anti-complement-factor H-associated glomerulopathies

Nature Reviews Nephrology, 2016
Atypical haemolytic uraemic syndrome (aHUS), an important cause of acute kidney injury, is characterized by dysregulation of the complement pathway, frequent need for dialysis, and progression to end-stage renal disease. Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement ...
Marie-Agnes Dragon, Durey, Aditi, Sinha, Shambhuprasad Kotresh, Togarsimalemath, Arvind, Bagga   +3 more
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Sequence polymorphism of human complement factor H

Immunogenetics, 1988
Factor H is a major regulatory protein of the complement system. The complete cDNA coding sequence has been derived from overlapping clones, and a polymorphism at base 1277 has been characterized. In four clones there is a T at nucleotide 1277 and in two others there is a C.
Day, Anthony J.; id_orcid 0000-0002-1415-3134, Willis, Antony C., Ripoche, Jean, Sim, Robert B.   +3 more
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The Pleiotropy of Complement Factor H

JAMA Ophthalmology, 2023
Elizabeth J, Rossin, Lucia, Sobrin
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Ancient Origin of Human Complement Factor H

Journal of Molecular Evolution, 1998
We studied the evolutionary history of two homologous proteins of the human complement system, factor H (FH) and the alpha chain of the C4b binding protein (C4bpalpha), and included in this study the related proteins from the barred sand bass (P. nebulifer) and the nematode C. elegans. Phylogenetic trees inferred from individual short consensus repeats
J, Krushkal, C, Kemper, I, Gigli
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