Results 251 to 260 of about 16,352,795 (292)

Complement Factor H: Physiology and Pathophysiology

Seminars in Thrombosis and Hemostasis, 2001
The human plasma protein factor H, which is a multifunctional, multidomain protein, acts as a central regulator of the complement system. In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3 ...
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Ancient Origin of Human Complement Factor H

Journal of Molecular Evolution, 1998
We studied the evolutionary history of two homologous proteins of the human complement system, factor H (FH) and the alpha chain of the C4b binding protein (C4bpalpha), and included in this study the related proteins from the barred sand bass (P. nebulifer) and the nematode C. elegans. Phylogenetic trees inferred from individual short consensus repeats
J, Krushkal, C, Kemper, I, Gigli
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Complement regulator factor H in multiple sclerosis

Journal of Cellular Biochemistry, 2011
A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients. We have previously demonstrated raised serum fH levels in MS and here, an extended analysis, quantifying fH ...
Gillian, Ingram, Svetlana, Hakobyan, Samantha, Loveless, Neil, Robertson, B Paul, Morgan   +4 more
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The Pleiotropy of Complement Factor H

JAMA Ophthalmology, 2023
Elizabeth J, Rossin, Lucia, Sobrin
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Anti-complement-factor H-associated glomerulopathies

Nature Reviews Nephrology, 2016
Atypical haemolytic uraemic syndrome (aHUS), an important cause of acute kidney injury, is characterized by dysregulation of the complement pathway, frequent need for dialysis, and progression to end-stage renal disease. Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement ...
Marie-Agnes Dragon, Durey, Aditi, Sinha, Shambhuprasad Kotresh, Togarsimalemath, Arvind, Bagga   +3 more
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Sequence polymorphism of human complement factor H

Immunogenetics, 1988
Factor H is a major regulatory protein of the complement system. The complete cDNA coding sequence has been derived from overlapping clones, and a polymorphism at base 1277 has been characterized. In four clones there is a T at nucleotide 1277 and in two others there is a C.
Day, Anthony J.; id_orcid 0000-0002-1415-3134, Willis, Antony C., Ripoche, Jean, Sim, Robert B.   +3 more
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Complement factor H and hemolytic uremic syndrome

International Immunopharmacology, 2001
Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long.
Zipfel, Peter F., Skerka, Christine, Caprioli, Jessica, Manuelian, Tamara, Neumann, Hartmut P. H., Noris, Marina, Remuzzi, Giuseppe   +6 more
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Genetic polymorphism of complement factor H in cattle

Animal Genetics, 1990
Summary Bovine factor H was found to be polymorphic by the combined techniques of SDS‐polyacrylamide electrophoresis of bovine plasma and immunoblotting. Three phenotypes (S, SF, F) were identified in a sample population of 149 cattle. Variant S and F differed by an apparent molecular weight of 5000 daltons.
H, Tabel, H J, Groat, G J, Kraay, W P, Aston   +3 more
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The dysfunctions of complement factor H in lupus nephritis

Lupus, 2016
Objective Our previous study showed that plasma levels of factor H (FH) were significantly decreased in patients with lupus nephritis and reflected lupus nephritis activity. The aim of this study was to further investigate in vitro biofunctions of plasma FH in patients with lupus nephritis.
F-M, Wang, D, Song, Y, Pang, Y, Song, F, Yu, M-H, Zhao   +5 more
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Urinary Complement Factor H in Renal Disease

Nephron, 2002
<i>Background:</i> Complement factor H (hCFH) plays a key inhibitory role in the control of the alternative complement pathway. We examined whether urinary hCFH (U-hCFH) levels is useful as an indirect indicator of renal damage. <i>Methods:</i> Urine samples were obtained from 104 patients with renal disease. Urine was collected
Mariko, Tamano, Yoshinobu, Fuke, Morito, Endo, Isao, Ohsawa, Takayuki, Fujita, Hiroyuki, Ohi   +5 more
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