Results 251 to 260 of about 349,286 (299)

PolySialic Acid Nanoparticles Actuate Complement-Factor-H-Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related Macular Degeneration. [PDF]

Pharmaceuticals (Basel)
Peterson SL, Krishnan A, Patel D, Khanehzar A, Lad A, Shaughnessy J, Ram S, Callanan D, Kunimoto D, Genead MA, Tolentino MJ.   +10 more
europepmc   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression. [PDF]

Nat Commun
Zouache MA, Richards BT, Pappas CM, Anstadt RA, Liu J, Corsetti T, Matthews S, Seager NA, Schmitz-Valckenberg S, Fleckenstein M, Hubbard WC, Thomas J, Hageman JL, Williams BL, Hageman GS.   +14 more
europepmc   +1 more source

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

[Complement factor H and macular degeneration].

Gaceta medica de Mexico, 2005
openaire   +1 more source

The complement factor H‐related proteins

Immunological Reviews, 2016
SummaryThe role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR
Medjeral-Thomas, N, Pickering, MC
openaire   +4 more sources

Recombinant complement factor H in complement-mediated diseases [PDF]

, 2022
Complement Factor H (FH) is a 155-kDa plasma glycoprotein that regulates the alternative pathway of the complement system. Mutations or deficiencies in FH are associated with some cases of the kidney diseases C3 glomerulopathy and atypical haemolytic uraemic syndrome (aHUS).
Kerr, Heather
openaire   +4 more sources

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Functional Anatomy of Complement Factor H

Biochemistry, 2013
Factor H (FH) is a soluble regulator of the proteolytic cascade at the core of the evolutionarily ancient vertebrate complement system. Although FH consists of a single chain of similar protein modules, it has a demanding job description. Its chief role is to prevent complement-mediated injury to healthy host cells and tissues. This entails recognition
Elisavet, Makou, Andrew P, Herbert, Paul N, Barlow   +2 more
openaire   +2 more sources

The lectin self of complement factor H

Current Opinion in Structural Biology, 2017
Complement, a part of the humoral innate immune system, is divided into three pathways. The classical and mannose-binding lectin pathways are triggered by specific recognition of foreign targets. Conversely, the alternative pathway (AP) is actively down-regulated on host tissue.
openaire   +2 more sources

Complement regulator factor H in multiple sclerosis

Journal of Cellular Biochemistry, 2011
A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients. We have previously demonstrated raised serum fH levels in MS and here, an extended analysis, quantifying fH ...
Gillian, Ingram, Svetlana, Hakobyan, Samantha, Loveless, Neil, Robertson, B Paul, Morgan   +4 more
openaire   +2 more sources