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Complement Factor H: Physiology and Pathophysiology
Seminars in Thrombosis and Hemostasis, 2001The human plasma protein factor H, which is a multifunctional, multidomain protein, acts as a central regulator of the complement system. In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3 ...
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Plasma Complement factor H in Alzheimer's Disease
Journal of Alzheimer's Disease, 2015Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results.
Williams, Michael A. +5 more
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Urinary Complement Factor H in Renal Disease
Nephron, 2002<i>Background:</i> Complement factor H (hCFH) plays a key inhibitory role in the control of the alternative complement pathway. We examined whether urinary hCFH (U-hCFH) levels is useful as an indirect indicator of renal damage. <i>Methods:</i> Urine samples were obtained from 104 patients with renal disease. Urine was collected
Mariko, Tamano +5 more
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Elevated Complement Factor H Levels in Asthmatic Sputa
Journal of Clinical Immunology, 2012The alternative pathway of the complement system is known to play a role in the generation of asthmatic airway inflammation, but its regulatory complement protein, factor H has not been investigated in this disease.Our aim was to determine the local bronchial complement factor H (CFH) levels in asthma, and to investigate its relationship with ...
Weiszhár, Z. +7 more
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The lectin self of complement factor H
Current Opinion in Structural Biology, 2017Complement, a part of the humoral innate immune system, is divided into three pathways. The classical and mannose-binding lectin pathways are triggered by specific recognition of foreign targets. Conversely, the alternative pathway (AP) is actively down-regulated on host tissue.
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Isolation of bovine complement factor H.
Veterinary Immunology and Immunopathology, 1987A bovine serum protein, initially recognized by its inhibitory effect on the hemolytic activity of the bovine alternative pathway was isolated from fresh bovine serum by polyethylene glycol precipitation and chromatography on DEAE-Sephacel, CM-Sephadex A-50 and Sephadex G-200. The protein, a single chain polypeptide with an apparent molecular weight of
A, Mhatre, W P, Aston
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Genetic analysis of human complement factor H polymorphisms
ELECTROPHORESIS, 2007AbstractHuman complement factor H (factor H) is polymorphic, with five previously reported FH alleles and three previously reported HF alleles (HF*A, HF*B, and HF*Q0). The relationship between the FH and HF alleles is not clear, and the genetic basis of factor H phenotypes has not yet been identified.
Rie, Susukida +3 more
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Complement Factor H Polymorphism and Age-Related Macular Degeneration
Science, 2005A. Edwards +5 more
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