Results 41 to 50 of about 38,814 (311)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Prevalence-dependent use of serological tests for diagnosing glanders in horses

BMC Veterinary Research, 2009
Background The internationally mandatory complement fixation test (CFT) for testing of equine sera for the absence of glanders has repeatedly led to discrepant results. Not only do "false positive" sera pose a problem for the diagnostician and the animal
Scholz Holger C, Joseph Maria, Wernery Renate, Neubauer Heinrich, Zachariah Reena, Sprague Lisa D, Wernery Ulrich   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Serological Survey of Bovine Brucellosis in Cameroon

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2005
A serological survey was carried out at the abattoir of Dschang (West Cameroon) from August 2002 to July 2003 in order to determine the prevalence of bovine brucellosis.
O. Shey-Njila, M. Daouda, E. Nya, P. A. Zoli, K. Walravens, J. Godfroid, S. Geerts   +6 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Real Prevalence of Bovine Brucellosis in the Center of Ivory Coast

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2008
During a serosurveillance survey carried out from July to August 2005 in Ivory Coast, 660 sera were collected in the administrative regions of N’Zi Comoe and Lacs, in the central part of the country. The sera were used to determine the real prevalence of
M. Sanogo, B. Cissé, M. Ouattara, K. Walravens, N. Praet, D. Berkvens, E. Thys   +6 more
doaj   +1 more source

Seroepidemiology of Camel Brucellosis in and around Dire Dawa, Eastern Ethiopia

Veterinary Medicine International, 2022
Brucellosis is an infectious disease in domestic and wild animals with serious zoonotic and economic implication in humans, being more severe in developing countries.
Hika Waktole, Mohammed Aden, Hagos Ashenafi   +2 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A reação de fixação do complemento na tipificação de vírus da gripe isolados no Rio de Janeiro The complement fixation test in the typefication of influenza viruses isolated in Rio de Janeiro

Memorias do Instituto Oswaldo Cruz, 1976
O autor estudou, pela reação de fixação do complemento, amostras de vírus da gripe isoladas no Rio de janeiro, durante a epidemia de 1973. Preparou imunesoros em hamsters pela inoculação do líquido alantóide de embriões de galinha infectados.
J. Guilherme Lacorte
doaj   +1 more source