Results 171 to 180 of about 96,307 (191)

Interaction of vaccinia virus complement control protein with human complement proteins: Factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway

Molecular Immunology, 1998
Abstract Vaccinia virus complement control protein (VCP) is a virulence determinant of vaccinia virus that helps protect the virus from the complement attack of the host. To characterize the interaction of VCP with C3 and C4 and understand the mechanism by which VCP inactivates complement, we have expressed VCP in a yeast expression ...
A, Sahu, S N, Isaacs, A M, Soulika, J D, Lambris   +3 more
openaire   +2 more sources

Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46).

Journal of biochemistry, 1992
Proteolytic inactivation of C4b is a crucial step for regulation of the classical complement pathway. A plasma protease factor I and membrane cofactors, C3b/C4b receptor (CR1) and membrane cofactor protein (MCP), participate in the regulation of cell-bound C4b although the physiological potency of these cofactors remains unknown.
T, Masaki, M, Matsumoto, I, Nakanishi, R, Yasuda, T, Seya   +4 more
openaire   +2 more sources

Preferential inactivation of the C5 convertase of the alternative complement pathway by factor I and membrane cofactor protein (MCP)

Molecular Immunology, 1991
Human C3b bound to the ghost of sheep erythrocytes (E*) via activation of the alternative complement pathway (E*AC3b) consists of four major constituents on SDS-PAGE of 350, 260, 210 and 180 kDa. 350 kDa C3b is a dimeric form of C3b in which the alpha' chain of one C3b binds covalently to that of the other C3b.
T, Seya, M, Okada, M, Matsumoto, K S, Hong, T, Kinoshita, J P, Atkinson   +5 more
openaire   +2 more sources

Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes.

Diabetes, 2004
Micro- and macrovascular diseases are major causes of morbidity and mortality in the diabetic population, but the cellular and molecular mechanisms that link hyperglycemia to these complications remain incompletely understood. We proposed that in human diabetes, inhibition by glycation of the complement regulatory protein CD59 increases deposition of ...
Xuebin, Qin, Allison, Goldfine, Nicole, Krumrei, Luciano, Grubissich, Juan, Acosta, Michael, Chorev, Arthur P, Hays, Jose A, Halperin   +7 more
openaire   +1 more source

The IgA‐Binding Lectin Jacalin Induces Complement Activation by Inhibition of ‐Inactivator Function

Scandinavian Journal of Immunology, 1987
P. Hiemstra, A. Gorter, M. Stuurman, L. Es, M. Daha   +4 more
semanticscholar   +1 more source

Complement Regulatory Proteins and Related Diseases

, 2013
S. Meri, H. Jarva
semanticscholar   +1 more source

Synthetic protein-sugar conjugates as models for the complement-inactivating property of atopic allergens.

Clinical and experimental immunology, 1976
L, Berrens, P M, van Liempt
openaire   +2 more sources

Isoelectric focusing of components of the complement system and certain related proteins in human serum.

Immunological Communications, 1974
R. A. Nelson, E. Brebner
semanticscholar   +1 more source

Inactivation of chemotactic factor inactivator by cigarette smoke. A potential mechanism of modulating neutrophil recruitment to the lung.

American Review of Respiratory Disease, 1990
Richard A. Robbins, G. Gossman, K. J. Nelson, Sekiya Koyama, Austin B. Thompson, S. Rennard   +5 more
semanticscholar   +1 more source

[Functions and structure of complement inactivators in membrane proteins. 2). Decay-accelerating factor].

, 1988
Yukihiko Sugita
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