Results 41 to 50 of about 1,209,228 (250)

Targeted management of coexistent severe thrombophilias—A case report of a successful pregnancy despite paroxysmal nocturnal hemoglobinuria and hereditary protein C deficiency

eJHaem
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by the absence of complement regulatory proteins on the surface of erythrocytes, leading to intravascular hemolysis and thrombosis.
Julien Dereme, Matthew Goodyer, David Baud, Lorenzo Alberio, Francesco Grandoni, Mathilde Gavillet   +5 more
doaj   +1 more source

MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model. [PDF]

PLoS ONE, 2018
The complement and coagulation systems closely interact with each other. These interactions are believed to contribute to the proinflammatory and prothrombotic environment involved in the development of thrombotic complications in many diseases ...
Lorenz Jenny, József Dobó, Péter Gál, Gábor Pál, Wilbur A Lam, Verena Schroeder   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation

Frontiers in Immunology, 2020
Hemopexin is the main plasmatic scavenger of cell-free heme, released in the context of intravascular hemolysis or major cell injury. Heme is indispensable for the oxygen transport by hemoglobin but when released outside of the erythrocytes it becomes a ...
Victoria Poillerat, Thomas Gentinetta, Juliette Leon, Andreas Wassmer, Monika Edler, Carine Torset, Dandan Luo, Gerald Tuffin, Lubka T. Roumenina   +8 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Successful Birth After First‐Trimester Ravulizumab Exposure in a Patient With Paroxysmal Nocturnal Hemoglobinuria: A Case Report

eJHaem
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder treated with complement C5 inhibitors. While eculizumab (Ecu) has documented safety in pregnancy, data on ravulizumab (Rav) are scarce.
Tatsuki Morioka, Shoya Arai, Yumi Arai, Satoshi Konno, Katsuhiro Tokuda, Takuji Matsuo, Kensuke Matsumoto, Ryosuke Shirasaki, Jun Ooi, Chikara Kihira, Yukifumi Sasamori, Kazunori Nagasaka, Haruko Tashiro   +12 more
doaj   +1 more source

Phospholipid Binding Protein C Inhibitor (PCI) Is Present on Microparticles Generated In Vitro and In Vivo.

PLoS ONE, 2015
Protein C inhibitor is a secreted, non-specific serine protease inhibitor with broad protease reactivity. It binds glycosaminoglycans and anionic phospholipids, which can modulate its activity.
Katrin Einfinger, Sigrun Badrnya, Margareta Furtmüller, Daniela Handschuh, Herbert Lindner, Margarethe Geiger   +5 more
doaj   +1 more source

Sutimlimab for the Treatment of Cold Agglutinin Disease

HemaSphere, 2023
Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia and a bone marrow clonal lymphoproliferative disorder. Hemolysis in CAD is complement-dependent and mediated by the classical activation pathway.
Sigbjørn Berentsen
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs

Journal of Neuroinflammation, 2004
Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This
McGeer Patrick L, Klegeris Andis, Hosokawa Masato   +2 more
doaj   +1 more source