Results 31 to 40 of about 345,005 (304)

Amniotic fluid embolism pathophysiology suggests the new diagnostic armamentarium: β-tryptase and complement fractions C3-C4 are the indispensable working tools [PDF]

, 2015
Amniotic fluid embolism (AFE) is an uncommon obstetric condition involving pregnant women during labor or in the initial stages after delivery. Its incidence is estimated to be around 5.5 cases per 100,000 deliveries.
Busardo', FRANCESCO PAOLO, Fineschi, Vittorio, Frati, Paola, Zaami, Simona   +3 more
core   +2 more sources

Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

Frontiers in Immunology, 2021
Complement factor B (FB) mutant variants are associated with excessive complement activation in kidney diseases such as atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy and membranoproliferative glomerulonephritis (MPGN).
Sigridur Sunna Aradottir, Ann-Charlotte Kristoffersson, Lubka T. Roumenina, Anna Bjerre, Anna Bjerre, Pavlos Kashioulis, Runolfur Palsson, Runolfur Palsson, Diana Karpman   +8 more
doaj   +1 more source

Real-world clinical outcomes and treatment response in complement inhibitor experienced and naïve PNH patients prescribed pegcetacoplan in Europe and Canada

Hematology
Objectives This study investigated outcomes and response to pegcetacoplan in complement inhibitor naïve (CInaïve) and experienced (CIexp) PNH patients.Methods Data were drawn from the Adelphi PNH Disease Specific Programme™, a cross-sectional survey of ...
Jens Panse, Juan Carlos Vallejo Llamas, Koo Wilson, Zalmai Hakimi, Barbara Czech, Brianne Kerr, Sam Williamson, Yasmin Taylor, Niall Hatchell, Christopher J. Patriquin   +9 more
doaj   +1 more source

Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammationResearch in context

EBioMedicine, 2019
Background: The complement and kallikrein-kinin systems (KKS) are activated during vascular inflammation. The aim of this study was to investigate if blockade of the KKS can affect complement activation on the endothelium during inflammation.
Ingrid Lopatko Fagerström, Anne-lie Ståhl, Maria Mossberg, Ramesh Tati, Ann-Charlotte Kristoffersson, Robin Kahn, Jean-Loup Bascands, Julie Klein, Joost P. Schanstra, Mårten Segelmark, Diana Karpman   +10 more
doaj   +1 more source

MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model. [PDF]

PLoS ONE, 2018
The complement and coagulation systems closely interact with each other. These interactions are believed to contribute to the proinflammatory and prothrombotic environment involved in the development of thrombotic complications in many diseases ...
Lorenz Jenny, József Dobó, Péter Gál, Gábor Pál, Wilbur A Lam, Verena Schroeder   +5 more
doaj   +1 more source

The emerging role of complement inhibitors in transplantation [PDF]

Kidney International, 2015
The role of complement in the biology of kidney transplantation is becoming more and more significant, especially but not only because we now have access to drugs inhibiting complement. After describing the main characteristics of complement biology, both activation of the complement cascade and the many regulatory factors, we will review the precise ...
Véronique, Frémeaux-Bacchi, Christophe M, Legendre   +1 more
openaire   +2 more sources

Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice

Journal of Neuroinflammation, 2012
Background The neuronal microtubule-associated protein tau becomes hyperphosphorylated and forms aggregates in tauopathies but the processes leading to this pathological hallmark are not understood.
Britschgi Markus, Takeda-Uchimura Yoshiko, Rockenstein Edward, Johns Hudson, Masliah Eliezer, Wyss-Coray Tony   +5 more
doaj   +1 more source

Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation

Frontiers in Immunology, 2020
Hemopexin is the main plasmatic scavenger of cell-free heme, released in the context of intravascular hemolysis or major cell injury. Heme is indispensable for the oxygen transport by hemoglobin but when released outside of the erythrocytes it becomes a ...
Victoria Poillerat, Thomas Gentinetta, Juliette Leon, Andreas Wassmer, Monika Edler, Carine Torset, Dandan Luo, Gerald Tuffin, Lubka T. Roumenina   +8 more
doaj   +1 more source

Sutimlimab for the Treatment of Cold Agglutinin Disease

HemaSphere, 2023
Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia and a bone marrow clonal lymphoproliferative disorder. Hemolysis in CAD is complement-dependent and mediated by the classical activation pathway.
Sigbjørn Berentsen
doaj   +1 more source

Complement Inhibitors And Glomerulonephritis [PDF]

Journal of the American Society of Nephrology, 2003
I recently gave a talk at a European nephrologic gathering on future therapies for glomerulonephritis (GN). It relied heavily on data from established animal models of renal disease. At the end, the first comment came from a very stern and unhappy-looking clinical nephrologist at the back of ...
openaire   +1 more source