Results 11 to 20 of about 345,005 (304)
Plasminogen Is a Complement Inhibitor [PDF]
Journal of Biological Chemistry, 2012 Plasminogen is a 92-kDa single chain glycoprotein that circulates in plasma as a zymogen and when converted to proteolytically active plasmin dissolves preformed fibrin clots and extracellular matrix components. Here, we characterize the role of plasmin(ogen) in the complement cascade.
Diana, Barthel +2 more
openaire +2 more sources
One-year efficacy and safety of ravulizumab in adults with paroxysmal nocturnal hemoglobinuria naïve to complement inhibitor therapy: open-label extension of a randomized study [PDF]
Therapeutic Advances in Hematology, 2020 Hubert Schrezenmeier +2 more
exaly +2 more sources
Frontiers in Immunology, 2022 Organ shortages and an expanding waitlist have led to increased utilization of marginal organs. All donor organs are subject to varying degrees of IRI during the transplant process.
Isabel F. Delaura +6 more
doaj +1 more source
Complement inhibitors for kidney disease
Nephrology Dialysis Transplantation, 2023 ABSTRACT A refined understanding of the role of complement in the pathogenesis of glomerular and other kidney diseases has, over the past two decades, been matched by the development of novel, complement-targeting therapies. As we increasingly recognize the important role that complement activation across all three pathways—classical ...
Benjamin, Wooden +3 more
openaire +2 more sources
Frontiers in Immunology, 2023 BackgroundA series of clinical trials support the effectiveness of monoclonal antibodies for generalized myasthenia gravis (MG) compared to the placebo, but the priority among drugs remains unclear.
Huiru Chen +10 more
doaj +1 more source
Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices
Frontiers in Immunology, 2021 Complement activation is key to anti-microbial defenses by directly acting on microbes and indirectly by triggering cellular immune responses. Complement activation may also contribute to the pathogenesis of numerous inflammatory and immunological ...
Sinan Muldur +8 more
doaj +1 more source
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]
, 2016 Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M. +18 more
core +1 more source
The case of complement inhibitors
Advances in Biological Regulation, 2021 Severe COVID-19 is characterized by lung and multiorgan inflammation and coagulation in the presence of overactivation of the complement system. Complement is a double edged-sward in SARS-Cov-2 infection. On one hand, it can control the viral infection in milder cases, on the other hand in cases with severe and prolonged infection massive complement ...
openaire +2 more sources
Complement receptor is an inhibitor of the complement cascade. [PDF]
The Journal of experimental medicine, 1981 A glycoprotein from the membrane of human erythrocytes has been identified as a receptor for C3b (CR1). It promotes the dissociation of the alternative pathway C3 convertase C3b,Bb and the cleavage of C3b by C3b/C4b inactivator. We find that CR1 also inactivates the C3 and C5 convertases of the classical pathway.
K, Iida, V, Nussenzweig
openaire +2 more sources
Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
core +1 more source