Results 11 to 20 of about 177,002 (299)

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

Frontiers in Immunology, 2020
The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies.
Nick S. Laursen, Dennis V. Pedersen, Heidi Gytz, Alessandra Zarantonello, Jens Magnus Bernth Jensen, Annette G. Hansen, Steffen Thiel, Gregers R. Andersen   +7 more
doaj   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy [PDF]

, 2016
Membranous nephropathy (MN), a major cause of nephrotic syndrome, is a non-inflammatory immune kidney disease mediated by IgG antibodies that form glomerular subepithelial immune complexes.
Dorin-Bogdan Borza
core   +8 more sources

Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery

Molecules, 2020
The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases.
Blake R. Rushing, Denise L. Rohlik, Sourav Roy, D. Andrew Skaff, Brandon L. Garcia   +4 more
doaj   +1 more source

Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential

Frontiers in Immunology, 2014
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp, Pamela H. Whitley, Kenji M. Cunnion, Kenji M. Cunnion, Neel Kumar Krishna, Neel Kumar Krishna   +5 more
doaj   +1 more source

Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis

Renal Failure, 2022
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima, Dan Inoue, Takeaki Wajima, Takahiro Uchida, Muneharu Yamada, Isao Ohsawa, Takashi Oda   +6 more
doaj   +1 more source

SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]

, 2016
Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M., Brandt, E.A., Collin, N., Coutinho-Abreu, I.V., Fazito Vale, V., Ferreira Mendes-Sousa, A., Ferreira, V.P., Gontijo, N.F., Horácio Pereira, M., Kamhawi, S., Kotsyfakis, M., Lima, K.F., Meneses, C., Nascimento Araújo, R., Oliveira, F., Pangburn, M.K., Rasouli, M., Ribeiro, J.M., Valenzuela, J.G.   +18 more
core   +1 more source

FUNCTIONAL ACTIVITY OF COMPLEMENT CLASSIC WAY ACTIVATION COMPONENTS AND ART1CULAS DAMAGE IN RHEUMATOID ARTRITIS

Научно-практическая ревматология, 2000
A relationship between X - ray joints changes and functional activity of classical pathway complement components in R4 was investigated. 31 patients with the moderate activity ofRA (ARA 1987) have been examined. Disease duration was 4,5lyear±3,84 (SD). X-
D. L. Goryachev, T. V. Lebedeva
doaj   +1 more source

Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (Cyprinus carpio)

Journal of Marine Science and Engineering, 2023
In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah, Akira Yamamoto, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao   +4 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources