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The Classical Pathway of Complement
2016Complement evolved in parallel with coagulation as part of the primordial explosion of life in the Cambrian era. Remnants of this connection still exist in vertebrate animals as well as invertebrates. A classic example is the horseshoe crab, Limulus polyphemus, still sought after by scientists today to test substances for traces of bacterial ...
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The non-classical functions of the classical complement pathway recognition subcomponent C1q
Immunology Letters, 2010C1q, the ligand recognition subcomponent of the classical complement pathway has steadily been gaining recognition as a bridge between innate and adaptive immunity. C1q has been shown to be involved in the modulation of various immune cells (such as dendritic cells, platelets, microglia cells and lymphocytes), clearance of apoptotic cells, a range of ...
Annapurna, Nayak +3 more
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Activation of the Classic and Alternate Complement Pathways by Endotoxin
The Journal of Immunology, 1974Abstract The ability of bacterial endotoxin (LPS) to activate the complement system was studied in guinea pig serum (GPS). In serum chelated with ethyleneglycol tetraacetic acid (EGTA) 10 mM, which permits alternate complement pathway activation but inhibits classic complement pathway activation, lysis of LPS-coated sheep erythrocytes (E-
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Adiponectin binds C1q and activates the classical pathway of complement
Biochemical and Biophysical Research Communications, 2008The adipose-specific protein adiponectin binds to a number of target molecules, including damaged endothelium and the surface of apoptotic cells. However, the significance of this binding remains unclear. This study demonstrates the binding of purified C1q to recombinant adiponectin under physiological conditions, and the dependence of this upon Ca(++)
Philip W, Peake +3 more
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The Classical Complement Pathway: Activation and Regulation of the First Complement Component
1985Publisher Summary This chapter focuses on the activation and regulation of the first complement component. . The chapter outlines the history of the classical pathway of the complement system. Clq and C1 are bound and activated by immune complexes or aggregates containing IgG or IgM but not by those containing IgA, IgD, or IgE . Among IgG subclasses,
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Succinylated and acetylated concanavalin A activate the classical complement pathway
Biochemical and Biophysical Research Communications, 1981Abstract Succinylated and acetylated concanavalin A, but not the native lectin, lyse sheep erythrocytes in the presence of guinea pig complement. The effect appears to be specific since succinylated wheat germ agglutinin is inactive and hemolysis is inhibited selectively by α-D-methylglucopyranoside. Hemolytic activity is enhanced by preincubation of
J J, Langone, R, Ejzemberg
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The classical and alternate pathways of complement in oral contraceptive users
Contraception, 1987Whole complement (CH50), C3, C4, the alternate pathway activity of complement (APH50) and factor B were measured in 159 women currently taking oral contraceptives and in 186 women who were not taking the pill. The mean levels of all components of the complement, except APH50, were found to be elevated in current users compared to non-users.
J M, Delâge +2 more
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Activation of the classical pathway of complement by tobacco glycoprotein (TGP)
The Journal of Immunology, 1995Abstract Tobacco glycoprotein (TGP), a polyphenol-rich glycoprotein isolated from tobacco leaves, activates the classical complement pathway through a mechanism that appears to involve direct interaction with C1q. A binding site on C1q for TGP can be localized by competitive inhibition with DNA to a region located in the junction ...
S M, Koethe, K E, Nelson, C G, Becker
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Effects of anesthesia and operation on the classical pathway of complement activation
Clinical Immunology and Immunopathology, 1982Abstract The present study examined whether anesthesia and operation could alter serum complement function as reflected by CH 50 levels and individual component activity. Classical complement pathway function was significantly reduced, as reflected by lowered CH 50 levels, in patients undergoing anesthesia and operation.
R E, Lewis, J M, Cruse, J V, Richey
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Targeting Classical Complement Pathway to Treat Complement Mediated Autoimmune Diseases
2008Mice deficient for classical complement pathway (CCP) factor C4 are resistant to antibody and complement mediated experimental autoimmune myasthenia gravis (EAMG). Anti-C1q antibody administration before or following acetylcholine receptor immunization suppresses EAMG development by reducing lymph node cell IL-6 production and neuromuscular junction ...
Erdem, Tüzün +4 more
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