Results 261 to 270 of about 177,224 (285)

The Classical Pathway of Complement

2016
Complement evolved in parallel with coagulation as part of the primordial explosion of life in the Cambrian era. Remnants of this connection still exist in vertebrate animals as well as invertebrates. A classic example is the horseshoe crab, Limulus polyphemus, still sought after by scientists today to test substances for traces of bacterial ...
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Synthesis of classical pathway complement components by chondrocytes.

Immunology, 1996
Using immunohistochemical studies, C1q, C1s, C4 and C2 were detected in chondrocytes in normal human articular cartilage and macroscopically normal articular cartilage from the inferior surfaces of hip joints of patients with osteoarthritis. Using reverse-transcribed polymerase chain reaction (RT-PCR), mRNA for C1q, C1s, C4 and C2 was also detected in ...
Bradley, K., North, J., Saunders, D., Schwaeble, W., Jeziorska, M., Woolley, D. E., Whaley, K.   +6 more
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Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy

Blood
Abstract Complement-mediated thrombotic microangiopathy (CM-TMA) or hemolytic uremic syndrome, previously identified as atypical hemolytic uremic syndrome, is a TMA characterized by germ line variants or acquired antibodies to complement proteins and regulators.
Michael A. Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, George McNamara, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky   +9 more
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Classical pathway of complement activation in mammalian kidneys.

Immunology, 1994
Two monoclonal antibodies (mAb M4d2 and M4d3) specific for the alpha 2-fragment (C4d), and one antibody (mAb M4c3) specific for the gamma-chain of human complement protein C4, have been tested for cross-reactivity against mammalian complement. These mAb have also been found to react with C4 from guinea-pig (mAb M4d2 and M4c3) as well as from cattle ...
J, Zwirner, E, Felber, R, Burger, D, Bitter-Suermann, G, Riethmüller, H E, Feucht   +5 more
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Classical Complement Pathway in Experimental Autoimmune Myasthenia Gravis Pathogenesis

Annals of the New York Academy of Sciences, 2008
Mice deficient for complement factors C3, C4, or C5 are resistant to experimental autoimmune myasthenia gravis (EAMG). Acetylcholine receptor (AChR) immune lymph node cells (LNC) of C3 deficient mice produce less interleukin 6 (IL‐6), and EAMG‐resistant IL‐6 deficient mice have less serum C3.
Premkumar, Christadoss, Erdem, Tüzün, Jing, Li, Shamsher S, Saini, Huan, Yang   +4 more
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The Classical Complement Pathway: Activation and Regulation of the First Complement Component

1985
Publisher Summary This chapter focuses on the activation and regulation of the first complement component. . The chapter outlines the history of the classical pathway of the complement system. Clq and C1 are bound and activated by immune complexes or aggregates containing IgG or IgM but not by those containing IgA, IgD, or IgE . Among IgG subclasses,
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CLASSICAL COMPLEMENT PATHWAY IN HIV INFECTION

The Lancet, 1989
G, Senaldi, M, Peakman, T, McManus, E T, Davies, D E, Tee, D, Vergani   +5 more
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Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Hemolytic Uremic Syndrome

AbstractComplement-mediated hemolytic uremic syndrome (CM-HUS) is a thrombotic microangiopathy characterized by germline variants or acquired antibodies to complement proteins and regulators. Building upon our prior experience with the modified Ham (mHam) assay for ex vivo diagnosis of complementopathies, we have developed an array of cell-based ...
Michael A. Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky   +8 more
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Classical Complement Pathway

2016
Odette Middleton, Helen Wheadon, Alison M. Michie   +2 more
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Classical pathway complement activation in association with paraproteinaemia.

Immunology, 1978
Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four.
P F, Naish, C, Collins, J, Barratt
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