Results 271 to 280 of about 248,329 (336)

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Chemoenzymatic Synthesis of Glycosphingolipids Having an HNK-1 Epitope for Erythrocyte Cell Surface Remodeling. [PDF]

J Am Chem Soc
Bunyatov MI, Boons GJ.
europepmc   +1 more source

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

Advanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou   +15 more
wiley   +1 more source

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation. [PDF]

Respir Res
Shivshankar P, Mueller-Ortiz SL, Domozhirov AY, Bi W, Collum SD, Doursout MF, Patel M, LeFebvre IN, Akkanti B, Yau S, Huang HJ, Hussain R, Karmouty-Quintana H.   +12 more
europepmc   +1 more source

Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene

Advanced Science, EarlyView.
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang, Chunyan Yin, Huaxiang Zhao, Yi Ding   +16 more
wiley   +1 more source

Immunological dysfunction of children with severe parapneumonic effusion. [PDF]

Front Pediatr
Rózsai B, Simon D, Berki T, Kiss G, Mosdósi B.   +4 more
europepmc   +1 more source

Complement C1q is associated with neuroinflammation and mediates the association between amyloid-β and tau pathology in Alzheimer's disease. [PDF]

Transl Psychiatry
Guo F, Sheng ZH, Fu Y, Wang ZB, Xue RJ, Tan L, Tan MS, Wang ZT.   +7 more
europepmc   +1 more source

Association of C4d with disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis: evidence for classical/lectin complement pathway activation. [PDF]

Arthritis Res Ther
Juto A, Martin M, Björk A, Padyukov L, Grönwall C, Antovic A, Bruchfeld A, Gunnarsson I, Blom AM.   +8 more
europepmc   +1 more source

<i>Staphylococcus aureus</i> SaeR/S-regulated factors overcome human complement-mediated inhibition of aggregation to evade neutrophil killing. [PDF]

Proc Natl Acad Sci U S A
Pettygrove BA, Nygaard TK, Borgogna TR, Malachowa N, Gaur G, Salo SE, Pallister KB, Burroughs O, Robinson C, Gao A, Sturdevant DE, Ricklefs S, DeLeo FR, Otto M, Stewart PS, Voyich JM.   +15 more
europepmc   +1 more source

Proteins of the SubB family provide multiple mechanisms of serum resistance in <i>Yersinia pestis</i>. [PDF]

Emerg Microbes Infect
Pierre F, Baillez A, Dewitte A, Rolandelli A, Sebbane F.   +4 more
europepmc   +1 more source