Results 281 to 290 of about 248,329 (336)

A percolation phase transition controls complement protein coating of surfaces. [PDF]

Cell
Wang Z, Kulkarni S, Nong J, Zamora M, Ebrahimimojarad A, Hood E, Shuvaeva T, Zaleski M, Gullipalli D, Wolfe E, Espy C, Arguiri E, Wu J, Wang Y, Marcos-Contreras OA, Song W, Muzykantov VR, Fu J, Radhakrishnan R, Myerson JW, Brenner JS.   +20 more
europepmc   +1 more source

Complement biosynthesis in human brain: Insights from single-nucleus transcriptomics of hippocampus

Nguyen VD, Bright M, Zhou Y, Morgan BP, Zelek WM.   +4 more
europepmc   +1 more source

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Classical complement pathway factor alterations in narcolepsy

Acta Neuropsychiatrica, 2022
AbstractObjective:Narcolepsy is a chronic sleep disorder long hypothesised to be an autoimmune disease. Complement-mediated immune mechanisms have not been investigated in detail in narcolepsy. Our aim was to establish the significance of classical pathway activation in narcolepsy.Methods:Sera of 42 narcolepsy patients and 26 healthy controls were ...
Hande Yüceer, Duygu Gezen Ak, Gülçin Benbir Şenel, Erdinç Dursun, Vuslat Yılmaz, Derya Karadeniz, Erdem Tüzün, Cem İsmail Küçükali   +7 more
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Classical pathway complement activity in schizophrenia

Neuroscience Letters, 2005
There is considerable evidence to suggest a role for complement in the pathogenesis of schizophrenia, but the data related to the classical pathway complement activity in patients with schizophrenia are conflicting. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3 ...
Robert B. Sim, Anna Boyajyan, Svetlana Hakobyan   +2 more
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Effect of Concanavalin A on the Classical Complement Pathway

The Journal of Immunology, 1977
Abstract Lysis of sheep erythrocytes (E) sensitized with anti-Forssman antiserum (EA) is inhibited by the action of concanavalin A (Con A) on whole guinea pig complement (GPC). The degree of inhibition observed for a given quantity of GPC was dependent on the Con A concentration.
J J, Langone, M D, Boyle, T, Borsos
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Will a hyperactive classical complement pathway exacerbate autoimmune diseases?

Autoimmunity Reviews, 2023
Peer ...
Okrój, Marcin, Rodríguez de Córdoba, Santiago   +1 more
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Control of the classical and the MBL pathway of complement activation

Molecular Immunology, 2000
The activation of complement via the mannan-binding lectin (MBL) pathway is initiated by the MBL complex consisting of the carbohydrate binding molecule, MBL, two associated serine proteases, MASP-1 and MASP-2, and a third protein, MAp19. In the present report we used an assay of complement activation specifically reflecting the physiological activity ...
Petersen, Steen Vang, Thiel, S, Jensen, L, Vorup-Jensen, T, Koch, C, Jensenius, J C   +5 more
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Interaction of fucoidan with the complement proteins of the classical pathway

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
Fucoidan inhibits complement by mechanisms that so far remain to be unraveled, and the objective of this work was to delineate the mode of inhibition by this sulfated polysaccharide. For that purpose, low molecular weight fractions of algal (Ascophyllum nodosum) fucoidan containing the disaccharide unit [-->3)-alpha-L-Fuc(2SO3(-))-(1-->4)-alpha-L-Fuc(2,
Tissot, B., Montdargent, B., Chevolot, L., Varenne, A., Descroix, S., Gareil, P., Daniel, Régis   +6 more
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A novel ELISA for the evaluation of the classical pathway of complement

Journal of Immunological Methods, 1998
Assessment of the overall function of the classical pathway of complement is traditionally performed by the hemolytic titration assay CH50. In the present study, we established a novel method for the quantitation of complement activity by measuring the deposition of C1q, C4, C3 and C9 on solid-phase IgM by an enzyme-linked immunosorbent assay (ELISA ...
Otto Götze, A Wittig, Jörg Zwirner, E Kremmer   +3 more
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