Results 291 to 300 of about 248,329 (336)
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Activation of the classical complement pathway by BioRex-70
Immunology Letters, 1987The cation exchange resin BioRex-70 was able to activate the classical complement pathway in human serum at 37 degrees C over the resin concentration range 0-5% (v/v). Using zymosan-treated human serum, it was found that the activation proceeded as far as complement protein C3.
S.B. Easterbrook-Smith, R.J. Vandenberg
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Classical pathway complement activation in Kawasaki syndrome
Journal of Allergy and Clinical Immunology, 1994In this study the complement breakdown products C3d, C4d, Bb and membrane attack complex were measured in plasma of patients with Kawasaki syndrome. The results suggested strong activation of the classical activation pathway. However, there was no significant decrease in hemolytic titer or in the concentrations of the intact proteins C3, C4, and B. The
Toshinori Asahina +3 more
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The Classical Pathway of Complement [PDF]
, 2016 Complement evolved in parallel with coagulation as part of the primordial explosion of life in the Cambrian era. Remnants of this connection still exist in vertebrate animals as well as invertebrates. A classic example is the horseshoe crab, Limulus polyphemus, still sought after by scientists today to test substances for traces of bacterial ...
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An immunofluorescence assay for complement activation by the classical pathway
Journal of Immunological Methods, 1981The functional integrity of classical complement pathway components was determined by an immunofluorescence (IFL) assay based on the capacity of cytoskeletal intermediate filaments (IMF) to bind C1q and to activate the complement pathway. The assay uses IMF-rich capillary endothelium of human term placentae as complement-activating substrate.
S. Meri, M. Rhen, Ewert Linder
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complement classical and lectin pathways
2010The classical and lectin pathways of complement are major recognition systems of innate immunity that are found in mammals and other animal species. By means of several multimolecular proteases – C1, the mannan-binding lectin (MBL)–MBL-associated serine protease 2 (MBL–MASP-2) and the ficolin–MASP-2 complexes – each comprising a recognition protein and
Thielens, Nicole +2 more
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The non-classical functions of the classical complement pathway recognition subcomponent C1q.
Immunology Letters, 2010C1q, the ligand recognition subcomponent of the classical complement pathway has steadily been gaining recognition as a bridge between innate and adaptive immunity. C1q has been shown to be involved in the modulation of various immune cells (such as dendritic cells, platelets, microglia cells and lymphocytes), clearance of apoptotic cells, a range of ...
Annapurna Nayak +3 more
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Classical pathway complement activity in Familial Mediterranean fever
Clinical Biochemistry, 2006The present study emphasizes the important role of the immune reactions in the pathogenesis of Familial Mediterranean fever. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3, and C4, were determined in the blood serum of 32 patients with FMF and 28 healthy subjects ...
A.A. Ayvazyan . +3 more
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Alternate and Classical Pathway Components of Complement in the Normal Cornea
Archives of Ophthalmology, 1980Activation of complement by either the classical or alternate pathway may be involved in corneal inflammation. This study was undertaken to determine whether the normal human cornea contains components for both classical and alternate pathway activation of complement.
Daniel B. Goldberg +4 more
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Monoclonal Antibodies against Components of the Classical Pathway of Complement
Complement and Inflammation, 1989Activation of the classical pathway of complement involves several binding and enzymatic cleavage processes. Binding and enzymatic activation results in the appearance of new structures in the individual components. This report describes the different activation steps for C1q, C1r, C1s, C4 and C2 and summarizes monoclonal antibodies reported so far ...
Michael Loos, Hans-Peter Heinz
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Activation of the Classic and Alternate Complement Pathways by Endotoxin
The Journal of Immunology, 1974Abstract The ability of bacterial endotoxin (LPS) to activate the complement system was studied in guinea pig serum (GPS). In serum chelated with ethyleneglycol tetraacetic acid (EGTA) 10 mM, which permits alternate complement pathway activation but inhibits classic complement pathway activation, lysis of LPS-coated sheep erythrocytes (E-
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