Results 301 to 310 of about 248,329 (336)
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Targeting Classical Complement Pathway to Treat Complement Mediated Autoimmune Diseases
2008Mice deficient for classical complement pathway (CCP) factor C4 are resistant to antibody and complement mediated experimental autoimmune myasthenia gravis (EAMG). Anti-C1q antibody administration before or following acetylcholine receptor immunization suppresses EAMG development by reducing lymph node cell IL-6 production and neuromuscular junction ...
Jing Li +4 more
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The classical and alternate pathways of complement in oral contraceptive users
Contraception, 1987Whole complement (CH50), C3, C4, the alternate pathway activity of complement (APH50) and factor B were measured in 159 women currently taking oral contraceptives and in 186 women who were not taking the pill. The mean levels of all components of the complement, except APH50, were found to be elevated in current users compared to non-users.
G. Lehner-Netsch +2 more
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Succinylated and acetylated concanavalin A activate the classical complement pathway
Biochemical and Biophysical Research Communications, 1981Abstract Succinylated and acetylated concanavalin A, but not the native lectin, lyse sheep erythrocytes in the presence of guinea pig complement. The effect appears to be specific since succinylated wheat germ agglutinin is inactive and hemolysis is inhibited selectively by α-D-methylglucopyranoside. Hemolytic activity is enhanced by preincubation of
John J. Langone, Regina Ejzemberg
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Effects of anesthesia and operation on the classical pathway of complement activation
Clinical Immunology and Immunopathology, 1982Abstract The present study examined whether anesthesia and operation could alter serum complement function as reflected by CH 50 levels and individual component activity. Classical complement pathway function was significantly reduced, as reflected by lowered CH 50 levels, in patients undergoing anesthesia and operation.
Robert E. Lewis +2 more
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The Classical Complement Pathway: Activation and Regulation of the First Complement Component
1985Publisher Summary This chapter focuses on the activation and regulation of the first complement component. . The chapter outlines the history of the classical pathway of the complement system. Clq and C1 are bound and activated by immune complexes or aggregates containing IgG or IgM but not by those containing IgA, IgD, or IgE . Among IgG subclasses,
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Adiponectin binds C1q and activates the classical pathway of complement
Biochemical and Biophysical Research Communications, 2008The adipose-specific protein adiponectin binds to a number of target molecules, including damaged endothelium and the surface of apoptotic cells. However, the significance of this binding remains unclear. This study demonstrates the binding of purified C1q to recombinant adiponectin under physiological conditions, and the dependence of this upon Ca(++)
Alexandra Walther +3 more
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Synthesis of classical pathway complement components by chondrocytes.
Immunology, 1996Using immunohistochemical studies, C1q, C1s, C4 and C2 were detected in chondrocytes in normal human articular cartilage and macroscopically normal articular cartilage from the inferior surfaces of hip joints of patients with osteoarthritis. Using reverse-transcribed polymerase chain reaction (RT-PCR), mRNA for C1q, C1s, C4 and C2 was also detected in ...
Bradley, K. +6 more
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[22] Molecular titration of components of the classical complement pathway
1983Publisher Summary The complement system consists of at least 20 serum proteins that interact in a precisely defined sequence resulting in the production of biologically active by-products and, ultimately, in the destruction of, or damage to, a suitably sensitized cell. Activation of this system can be achieved by two mechanisms, namely, the classical
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CLASSICAL COMPLEMENT PATHWAY IN HIV INFECTION
The Lancet, 1989E T Davies +5 more
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