Results 71 to 80 of about 175,214 (207)

Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor Links Complement and Hemostasis-Thrombosis [PDF]

, 2013
Background: Vascular endothelial cells (ECs) express and release protein components of the complement pathways, as well as secreting and anchoring ultra-large von Willebrand factor (ULVWF) multimers in long string-like structures that initiate platelet ...
Moake, Joel, Turner, Nancy A.
core   +2 more sources

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Mathieson, PW, Oliveria, DB, Peters, DK, Würzner, R   +4 more
core   +1 more source

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.

PLoS ONE, 2015
The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases. Consequently, therapeutic modulators of the classical, lectin and alternative pathways of the complement system are ...
Julia A Sharp, Pamela S Hair, Haree K Pallera, Parvathi S Kumar, Clifford T Mauriello, Julius O Nyalwidhe, Cody A Phelps, Dalnam Park, Nicole M Thielens, Stephen M Pascal, Waldon Chen, Diane M Duffy, Frank A Lattanzio, Kenji M Cunnion, Neel K Krishna   +14 more
doaj   +1 more source

Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]

, 1991
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz, Alsenz, Aruffo, Chirgwin, Church, Conrad, Day, Feinberg, Fontaine, Kristensen, Laemmli, Maniatis, McAleer, Misasi, Pangburn, Ripoche, Schulz, Schulz, Schwaeble, Seed, Sim, Towbin, Whaley, Whaley   +23 more
core   +1 more source

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

Cell Reports, 2019
Summary: Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood.
Aleksandra Vukojicic, Nicolas Delestrée, Emily V. Fletcher, John G. Pagiazitis, Sethu Sankaranarayanan, Ted A. Yednock, Ben A. Barres, George Z. Mentis   +7 more
doaj   +1 more source

Human pentraxin 3 binds to the complement regulator c4b-binding protein.

PLoS ONE, 2011
The long pentraxin 3 (PTX3) is a soluble recognition molecule with multiple functions including innate immune defense against certain microbes and the clearance of apoptotic cells.
Anne Braunschweig, Mihály Józsi
doaj   +1 more source

Antibodies against C1q in patients with systemic lupus erythematosus [PDF]

, 2018
The first component of the classical pathway of complement (C1q) is considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE).
Trendelenburg, Marten
core  

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig- to-rat xenotransplantation [PDF]

, 1995
In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well ...
Adachi, Anthony J. Demetris, Cochrane, Gewurz, Hasan, Hideaki Miyazawa, Hong, Iida, Kissmeyer-Nielsen, Kitano, Kitano, Leventhal, Minoru Nomoto, Mitsuko Tanaka, Miyagawa, Miyagawa, Miyazaki, Miyazaki, Miyazawa, Murase, Nelson, Noriko Murase, Ono, Perper, Pruitt, Pruitt, Qing Ye, Rafael Manez, Satoru Todo, Soares, Starzl, Starzl, Starzl, Starzl, Tanaka, Thomas E. Starzl, Valdivia, Van den Bogaerde, Wasei Miyazaki, Xia, Yamamoto, Yoichi Toyama   +41 more
core   +2 more sources

Interaction of lactoferrin, lysozyme and the complement system in in vitro modeling of innate immune responses

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Complement is a key humoral participant of immunity involved in defensive and pathological processes. Human lysozyme (hLZ), hen egg white lysozyme (HEWL) and lactoferrin (LF) are classical constituents of innate immunity.
Ilia A. Krenev, Ekaterina S. Umnyakova, Alexey V. Sokolov, Nikolay P. Gorbunov, Valeria A. Kostevich, Galina M. Aleshina, Mikhail N. Berlov   +6 more
doaj   +1 more source