Results 111 to 120 of about 1,111,236 (286)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie, Sonja Grosskinsky, Markus M. Simon, Grosskinsky, Sonja, Cutler, Sally J., Schott, M., Simon, M., Kraiczy, P., Zipfel, Peter F., Grosskinsky, S., Peter Kraiczy, Sally J Cutler, Peter F Zipfel, Peter F. Zipfel, Brenner, Christiane, Wallich, R., Kraiczy, Peter, Brenner, C., Christiane Brenner, Simon, Markus M., Markus M Simon, Wallich, Reinhard, Sally J. Cutler, Reinhard Wallich, Cutler, S., Zipfel, P., Melanie Schott   +26 more
core   +2 more sources

Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors

mAbs
A critical attribute of therapeutic antibodies is their ability to engage with humoral or cellular effector mechanisms, and this depends on the ability of the Fc region to bind to complement (C1q) or Fc receptors.
Geoff Hale, Alastair Douglas Davy, Ian Wilkinson   +2 more
doaj   +1 more source

Nuclear receptor complement of the cnidarian Nematostella vectensis: phylogenetic relationships and developmental expression patterns

BMC Evolutionary Biology, 2009
Background Nuclear receptors are a superfamily of metazoan transcription factors that regulate diverse developmental and physiological processes.
Tarrant Ann M, Reitzel Adam M
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Complement Factor H: solution structures and interactions with ligands [PDF]

, 2009
Factor H (FH) is a plasma glycoprotein that plays a central role in regulating the alternative pathway of complement. It is composed of 20 short complement regulator (SCR) domains.
Okemefuna, A.I.
core  

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Bee K. Tan, Robert B. Sim, Russell Wallis, Tan, Bee K., Elizabeth J. Soilleux, Townsend, Paul, Wallis, Russell, Soilleux, Elizabeth J., Paul Townsend, Daniel A. Mitchell, Randeva, Harpal S., Sim, Robert B., Hendrik Lehnert, Ilyas, Rebecca, Zehnder, Daniel, Mitchell, Daniel A., Daniel Zehnder, Rebecca Ilyas, Harpal S. Randeva, Lehnert, Hendrik   +19 more
core   +1 more source

The role of complement in synaptic degeneration

, 2012
Synapse loss is an early event of many neurodegenerative diseases including Alzheimer?s disease and Parkinson?s disease. The causes and mechanisms that underpin synapse dysfunction and degeneration are poorly understood.
Malfa, Katya
core   +1 more source

Complement tumor-crosstalk: the role of C5a receptors in urothelial carcinomas

Frontiers in Immunology
Urothelial carcinoma, the second most common urological malignancy, can arise in both the lower and upper urinary tract, with approximately 90–95% arising in the bladder, while urothelial carcinomas of the upper urinary tract account for only 5–10 ...
Lea Sophie Lütje, Caroline Gruner, Christian Marcel Karsten, Axel Stuart Merseburger, Marie Christine Roesch   +4 more
doaj   +1 more source

Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study. [PDF]

BJOG, 2021
Lokki AI, Teirilä L, Triebwasser M, Daly E, Bhattacharjee A, Uotila L, Llort Asens M, Kurki MI, Perola M, Auro K, Salmon JE, Daly M, Atkinson JP, Laivuori H, Fagerholm S, Meri S, Finnpec.   +16 more
europepmc   +1 more source