Results 81 to 90 of about 197,380 (294)

Oxidative Stress Increases Endogenous Complement-Dependent Inflammatory and Angiogenic Responses in Retinal Pigment Epithelial Cells Independently of Exogenous Complement Sources. [PDF]

, 2019
Oxidative stress-induced damage of the retinal pigment epithelium (RPE) and chronic inflammation have been suggested as major contributors to a range of retinal diseases.
Nicole Schäfer, Schäfer, Nicole, Trakkides, Timon-Orest, Joachim Wegener, Kühn, Konstanze, Urban, Florian, Ricardo J. M. G. E. Brandwijk, Toonen, Erik J M, Florian Urban, Maria Reichenthaler, Pauly, Diana, Timon-Orest Trakkides, Reichenthaler, Maria, Enzmann, Volker, Volker Enzmann, Brandwijk, Ricardo J M G E, Wegener, Joachim, Konstanze Kühn, Diana Pauly, Erik J. M. Toonen   +19 more
core   +1 more source

Intracellular C3 regulates the immune response to infection via NF-κB signaling

Cellular and Molecular Life Sciences
Complement factor C3 is one of the most abundant proteins in the bloodstream and a central part of the complement system. Upon activation, C3 facilitates bacterial recognition and clearance in the extracellular environment.
Katarzyna Kuska, Serena Bettoni, Frida Mohlin, Maja Chrobak, Vaishnavi Dandavate, Saleh Moradi, Ben King, Kristian Riesbeck, Anna M. Blom   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Microvesicles in disease [PDF]

, 2014
On activation cells shed vesicles from their surface by the process of ectocytosis. These micro-vesicles or Ectosomes express phosphatidyl-serine (PS) on their surface, which can elicit a range of biological effects from immune-suppression to the ...
Čumpelik, Arun
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

, 2020
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Lee, John D., Monk, Peter, Mitolo, Vincenzo, Woodruff, Trent M., Coulthard, Liam, Cianciulli, Antonia, Panaro, Maria A., Li, Xiang X., Hawksworth, Owen   +8 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Characterization and functional analysis of mouse Ficolin B

, 2012
The innate immune system contributes day by day to the elimination of invading pathogens. The lectin pathway of the complement system is initiated when mannose-binding-lectin (MBL) or ficolins interact with MASP-2.
Hunold, Katja
core   +1 more source

Complement Evasion Strategies of Viruses: An Overview

Frontiers in Microbiology, 2017
Being a major first line of immune defense, the complement system keeps a constant vigil against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and trigger the effector pathways, results in neutralization of viruses ...
Palak Agrawal, Renuka Nawadkar, Hina Ojha, Jitendra Kumar, Arvind Sahu   +4 more
doaj   +1 more source