Results 211 to 220 of about 1,176 (261)
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Viral complement regulatory proteins
Immunopharmacology, 1999The inactivation of complement provides cells and tissues critical protection from complement-mediated attack and decreases the associated recruitment of other inflammatory mediators. In an attempt to evade the host immune response, viruses have evolved two mechanisms to acquire complement regulatory proteins.
Joseph M. Ahearn, Ariella M. Rosengard
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Membrane complement regulatory proteins
Clinical Immunology, 2006A number of proteins anchored on the cell surface function to protect host tissues from bystander injury when complement is activated. In humans, they include decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46), complement receptor 1 (CR1, CD35) and CD59. Although disease conditions directly attributable to abnormal function of
Wen-Chao Song, David Inhyuk Kim
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Complement-regulatory proteins in ovarian malignancies
International Journal of Cancer, 1997Ovarian cancer has features that makes it well-suited for MAb adjuvant immunotherapy. Several of the MAbs used in clinical trials mediate cancer cell destruction by activation of complement (C). In this study, therefore, we examined the ability of ovarian-tumor cells to resist C attack.
Seppo Meri +4 more
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Combination effects of complement regulatory proteins and anti-complement polymer
Biochimica et Biophysica Acta (BBA) - General Subjects, 2003We previously reported the development of a "cytomedicine" that consists of cells trapped in alginate-poly-L-lysine-alginate (APA) microcapsules and agarose microbeads. The functional cells that are entrapped in semipermeable polymer are completely isolated from cellular immune system.
Natsuki Dohi +10 more
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Exploitation of complement regulatory proteins by Borrelia and Francisella
Molecular BioSystems, 2015BorreliaandFrancisellainteract differently with complement regulatory proteins from various hosts, which influences the disease development and ecology of pathogens.
Renata Soares +13 more
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Complement and Complement Regulatory Proteins in Diabetes
2015In this chapter we have summarized the body of evidence that supports a role for the complement system and complement regulatory proteins in the pathogenesis of diabetic complications, with specific emphasis on the novel phenomenon of glycation-inactivation of CD59.
Anand Vaidya +3 more
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Molecular remodeling of complement regulatory proteins for xenotransplantation
Immunopharmacology, 1999In pig-to-human discordant xenotransplantation, human complement is a major barrier against long survival of xenografts. Human complement regulatory proteins expressed on xenografts have been adapted as safeguards against host-induced hyperacute rejection of xenografts.
Yusuke Murakami +5 more
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European Journal of Cardio-Thoracic Surgery, 1993
Cardiopulmonary bypass-induced organ dysfunction remains a clinical problem in certain groups of patients. Although the pathogenesis is multifactorial, it is likely that a panendothelial injury consequent upon widespread humoral and cellular activation is a major contributor to this process. The biologically active products of complement activation are
T W Evans, Neil Moat, Darryl F. Shore
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Cardiopulmonary bypass-induced organ dysfunction remains a clinical problem in certain groups of patients. Although the pathogenesis is multifactorial, it is likely that a panendothelial injury consequent upon widespread humoral and cellular activation is a major contributor to this process. The biologically active products of complement activation are
T W Evans, Neil Moat, Darryl F. Shore
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Complement and Complement Regulatory Proteins as Potential Molecular Targets for Vascular Diseases
Current Pharmaceutical Design, 2004By-products of complement activation and complement regulatory proteins are increasingly recognized to play an important pathogenic role in a variety of vascular diseases including atherosclerosis, ischemia and reperfusion injury, hyperacute graft rejection, vasculitis, and the vascular complications of human diabetes.
Xuebin Qin +2 more
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Advanced Materials, 2022
AbstractComplement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by the complement protein C3, leading to clearance by phagocytes, fouling of targeting moieties, and release of anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially
Zhicheng Wang +14 more
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AbstractComplement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by the complement protein C3, leading to clearance by phagocytes, fouling of targeting moieties, and release of anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially
Zhicheng Wang +14 more
openaire +2 more sources