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The role of complement and complement regulatory proteins in the progression of atherosclerosis [PDF]

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Viral complement regulatory proteins

Immunopharmacology, 1999
The inactivation of complement provides cells and tissues critical protection from complement-mediated attack and decreases the associated recruitment of other inflammatory mediators. In an attempt to evade the host immune response, viruses have evolved two mechanisms to acquire complement regulatory proteins.
J M Ahearn
exaly   +3 more sources

Membrane complement regulatory proteins

Clinical Immunology, 2006
A number of proteins anchored on the cell surface function to protect host tissues from bystander injury when complement is activated. In humans, they include decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46), complement receptor 1 (CR1, CD35) and CD59. Although disease conditions directly attributable to abnormal function of
Wen-Chao Song, David D Kim
exaly   +3 more sources

Molecular remodeling of complement regulatory proteins for xenotransplantation

Immunopharmacology, 1999
In pig-to-human discordant xenotransplantation, human complement is a major barrier against long survival of xenografts. Human complement regulatory proteins expressed on xenografts have been adapted as safeguards against host-induced hyperacute rejection of xenografts.
Tsukasa Seya, S Mikata, Shigeharu Nagasawa   +2 more
exaly   +3 more sources

Complement-regulatory proteins in ovarian malignancies

International Journal of Cancer, 1997
Ovarian cancer has features that makes it well-suited for MAb adjuvant immunotherapy. Several of the MAbs used in clinical trials mediate cancer cell destruction by activation of complement (C). In this study, therefore, we examined the ability of ovarian-tumor cells to resist C attack.
L, Bjørge, J, Hakulinen, T, Wahlström, R, Matre, S, Meri   +4 more
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Combination effects of complement regulatory proteins and anti-complement polymer

Biochimica et Biophysica Acta (BBA) - General Subjects, 2003
We previously reported the development of a "cytomedicine" that consists of cells trapped in alginate-poly-L-lysine-alginate (APA) microcapsules and agarose microbeads. The functional cells that are entrapped in semipermeable polymer are completely isolated from cellular immune system.
Yasuo, Yoshioka, Ryo, Suzuki, Takayuki, Okamoto, Naoki, Okada, Yohei, Mukai, Hiroko, Shibata, Yasuo, Tsutsumi, Natsuki, Dohi, Noriko, Okada, Shinsaku, Nakagawa, Tadanori, Mayumi   +10 more
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Complement and Complement Regulatory Proteins in Diabetes

2015
In this chapter we have summarized the body of evidence that supports a role for the complement system and complement regulatory proteins in the pathogenesis of diabetic complications, with specific emphasis on the novel phenomenon of glycation-inactivation of CD59.
Jose A. Halperin, Pamela Ghosh, Michael Chorev, Anand Vaidya   +3 more
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Complement and Complement Regulatory Proteins as Potential Molecular Targets for Vascular Diseases

Current Pharmaceutical Design, 2004
By-products of complement activation and complement regulatory proteins are increasingly recognized to play an important pathogenic role in a variety of vascular diseases including atherosclerosis, ischemia and reperfusion injury, hyperacute graft rejection, vasculitis, and the vascular complications of human diabetes.
Juan, Acosta, Xuebin, Qin, Jose, Halperin   +2 more
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Complement Regulatory Proteins and Autoimmunity

2001
To discriminate self from non-self is an essential issue in the immune system. Autologous cells are protected against complement-mediated cell injury by the self-recognition mechanism using complement regulatory proteins composed of complement receptor type 1 (CR1, CD35), membrane cofactor protein (MCP, CD46), decay accelerating factor (DAF, CD55) and ...
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