Results 251 to 260 of about 140,468 (298)
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Membrane complement regulatory proteins
Clinical Immunology, 2006A number of proteins anchored on the cell surface function to protect host tissues from bystander injury when complement is activated. In humans, they include decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46), complement receptor 1 (CR1, CD35) and CD59. Although disease conditions directly attributable to abnormal function of
Wen-Chao Song, David Inhyuk Kim
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Complement-regulatory proteins in ovarian malignancies
International Journal of Cancer, 1997Ovarian cancer has features that makes it well-suited for MAb adjuvant immunotherapy. Several of the MAbs used in clinical trials mediate cancer cell destruction by activation of complement (C). In this study, therefore, we examined the ability of ovarian-tumor cells to resist C attack.
Seppo Meri +4 more
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Combination effects of complement regulatory proteins and anti-complement polymer
Biochimica et Biophysica Acta (BBA) - General Subjects, 2003We previously reported the development of a "cytomedicine" that consists of cells trapped in alginate-poly-L-lysine-alginate (APA) microcapsules and agarose microbeads. The functional cells that are entrapped in semipermeable polymer are completely isolated from cellular immune system.
Natsuki Dohi +10 more
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Exploitation of complement regulatory proteins by Borrelia and Francisella
Molecular BioSystems, 2015BorreliaandFrancisellainteract differently with complement regulatory proteins from various hosts, which influences the disease development and ecology of pathogens.
Renata Soares +13 more
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Complement and Complement Regulatory Proteins in Diabetes
2015In this chapter we have summarized the body of evidence that supports a role for the complement system and complement regulatory proteins in the pathogenesis of diabetic complications, with specific emphasis on the novel phenomenon of glycation-inactivation of CD59.
Anand Vaidya +3 more
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Molecular remodeling of complement regulatory proteins for xenotransplantation
Immunopharmacology, 1999In pig-to-human discordant xenotransplantation, human complement is a major barrier against long survival of xenografts. Human complement regulatory proteins expressed on xenografts have been adapted as safeguards against host-induced hyperacute rejection of xenografts.
Yusuke Murakami +5 more
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European Journal of Cardio-Thoracic Surgery, 1993
Cardiopulmonary bypass-induced organ dysfunction remains a clinical problem in certain groups of patients. Although the pathogenesis is multifactorial, it is likely that a panendothelial injury consequent upon widespread humoral and cellular activation is a major contributor to this process. The biologically active products of complement activation are
T W Evans, Neil Moat, Darryl F. Shore
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Cardiopulmonary bypass-induced organ dysfunction remains a clinical problem in certain groups of patients. Although the pathogenesis is multifactorial, it is likely that a panendothelial injury consequent upon widespread humoral and cellular activation is a major contributor to this process. The biologically active products of complement activation are
T W Evans, Neil Moat, Darryl F. Shore
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Complement Regulatory Proteins and Autoimmunity
2001To discriminate self from non-self is an essential issue in the immune system. Autologous cells are protected against complement-mediated cell injury by the self-recognition mechanism using complement regulatory proteins composed of complement receptor type 1 (CR1, CD35), membrane cofactor protein (MCP, CD46), decay accelerating factor (DAF, CD55) and ...
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Complement and Complement Regulatory Proteins as Potential Molecular Targets for Vascular Diseases
Current Pharmaceutical Design, 2004By-products of complement activation and complement regulatory proteins are increasingly recognized to play an important pathogenic role in a variety of vascular diseases including atherosclerosis, ischemia and reperfusion injury, hyperacute graft rejection, vasculitis, and the vascular complications of human diabetes.
Xuebin Qin +2 more
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C4b-Binding protein, a regulatory protein of complement
Immunologic Research, 1991Despite the wealth of structural and functional information on C4BP, it is clear that several aspects of C4BP biology and regulation under normal conditions and in the acute-phase response remain unresolved. Studies to identify which interleukin and cytokines regulate C4BP expression (both α-and β-chains) are underway in our laboratory.
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