A deflated Schur complement method for the iterative solution of a high-order discontinuous element discretization of the Poisson equation [PDF]
A combination of block-Jacobi and deflation preconditioning is used to solve a high-order discontinuous element-based collocation discretization of the Schur complement of the Poisson-Neumann system as arises in the operator splitting of the incompressible Navier-Stokes equations.
arxiv
Observations on the Sensitivity of the Haemolytic System in Complement-fixation Tests [PDF]
Hannah Rice
openalex +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Effective Implementation of the Weak Galerkin Finite Element Methods for the Biharmonic Equation [PDF]
The weak Galerkin (WG) methods have been introduced in the references [11, 16] for solving the biharmonic equation. The purpose of this paper is to develop an algorithm to implement the WG methods effectively. This can be achieved by eliminating local unknowns to obtain a global system with significant reduction of size.
arxiv
IMMUNOLOGICAL STUDIES OF THE 11S PROTEIN COMPONENT OF THE HUMAN COMPLEMENT SYSTEM [PDF]
Jane H. Morse, Charles L. Christian
openalex +1 more source
A potential tumor suppressor role of PLK2 in glioblastoma
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia+5 more
wiley +1 more source
Editorial: The complement system in autoimmunity
Eveline Y. Wu+6 more
doaj +1 more source
INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDE: CONSUMPTION OF EACH OF THE SIX TERMINAL COMPLEMENT COMPONENTS [PDF]
H Gewurz, H S Shin, S. E. Mergenhagen
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Identification of inhibitors of the Salmonella FraB deglycase, a drug target
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law+6 more
wiley +1 more source
Editorial: Complement in nervous system disease
Iliana Michailidou+4 more
doaj +1 more source