Results 101 to 110 of about 1,857,462 (287)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
We present optimal preconditioners for a recently introduced hybridized discontinuous Galerkin finite element discretization of the Stokes equations.
Rhebergen, Sander, Wells, Garth N.
core +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
On the cohomology of discriminantal arrangements and Orlik-Solomon algebras
We relate the cohomology of the Orlik-Solomon algebra of a discriminantal arrangement to the local system cohomology of the complement. The Orlik-Solomon algebra of such an arrangement (viewed as a complex) is shown to be a linear approximation of a ...
Cohen, Daniel C.
core +1 more source
Weighted BFBT Preconditioner for Stokes Flow Problems with Highly Heterogeneous Viscosity
We present a weighted BFBT approximation (w-BFBT) to the inverse Schur complement of a Stokes system with highly heterogeneous viscosity. When used as part of a Schur complement-based Stokes preconditioner, we observe robust fast convergence for Stokes ...
Ghattas, Omar +2 more
core +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Role of complement C3 in diabetic nephropathy
Linchuang shenzangbing zazhi, 2022 As one of the most common microvascular complications of diabetes， diabetic kidney disease （DKD） is one of the major causes of end-stage renal disease. Complement system participates in both innate and adaptive immunities of human body. Three pathways of
Wang Qing-qing +3 more
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Design and breadboard evaluation of the SPS reference phase control system concept [PDF]
The total breadboard system includes one pilot transmitter, one pilot receiver, nine phase distribution units, and two power transponders. With this complement of equipment, segments of a typical phase distribution system can be assembled to facilitate ...
Hopkins, P. M., Rao, V. R.
core